A0A7M1IFC9 · A0A7M1IFC9_9EURO
- ProteinSqualene monooxygenase
- Geneerg1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids453 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Catalytic activity
- O2 + reduced [NADPH--hemoprotein reductase] + squalene = (S)-2,3-epoxysqualene + H+ + H2O + oxidized [NADPH--hemoprotein reductase]
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | squalene monooxygenase activity | |
Biological Process | ergosterol biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSqualene monooxygenase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton
Accessions
- Primary accessionA0A7M1IFC9
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Microsome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-39 | Helical | ||||
Sequence: ADVVIIGAGIAGCALAVALG |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-51 | FAD dependent oxidoreductase | ||||
Sequence: DVVIIGAGIAGCALAVALGNQGRSVILLERS | ||||||
Domain | 172-446 | Squalene epoxidase | ||||
Sequence: GPLTVVADGYASTFRKEYLPIQPVAKSKFWGLELIDAKLPIPGHGHVVLGDFPPILIYQIGEHETRILIDIPDNLPSASVANGGVKGHMRNVVLPSLPECIRPSFEAALEKGGFRSMPNSFLRPVTNRIPGLMFLGDSLNMRHPLTGGGMTVAFNDVVLLRNLLSPEAVPDLSDTKLVLKQLSKFHWQRKSLISVINILAQSLYSIFAAGDPNLKVLQRGCFRYFQLGLIDGPIGLLSGIIRSPLVLLRHFYSVAFLAIWLHLTSKPIYLLPLTL |
Sequence similarities
Belongs to the squalene monooxygenase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length453
- Mass (Da)49,904
- Last updated2023-05-03 v1
- ChecksumAC2BA9DFC324FCDB
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: A | ||||||
Non-terminal residue | 453 | |||||
Sequence: F |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MT700503 EMBL· GenBank· DDBJ | QOQ37935.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT700509 EMBL· GenBank· DDBJ | QOQ37941.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT700519 EMBL· GenBank· DDBJ | QOQ37951.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT700520 EMBL· GenBank· DDBJ | QOQ37952.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT700521 EMBL· GenBank· DDBJ | QOQ37953.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT700522 EMBL· GenBank· DDBJ | QOQ37954.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MT700525 EMBL· GenBank· DDBJ | QOQ37957.1 EMBL· GenBank· DDBJ | Genomic DNA |