A0A7M1IFC9 · A0A7M1IFC9_9EURO

Function

function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionsqualene monooxygenase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Squalene monooxygenase
  • EC number

Gene names

    • Name
      erg1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 200874/20
    • 203513/19
    • 218160/18
    • 218676/19
    • 219238/19
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton

Accessions

  • Primary accession
    A0A7M1IFC9

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Microsome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-39Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-51FAD dependent oxidoreductase
Domain172-446Squalene epoxidase

Sequence similarities

Belongs to the squalene monooxygenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    453
  • Mass (Da)
    49,904
  • Last updated
    2023-05-03 v1
  • Checksum
    AC2BA9DFC324FCDB
AKPKAYRDEAERRRYEHHEADVVIIGAGIAGCALAVALGNQGRSVILLERSLKEPDRIVGELLQPGGVRALEQLGLRDCLEGIDAVRTYGYDVIYFGNGVKIPFPSDANDKILEGRCFHHGRFIMRLREAAAANPNVTIVETKAVSTIKSTHTGDVLGVQCQTDGKQDFYFGPLTVVADGYASTFRKEYLPIQPVAKSKFWGLELIDAKLPIPGHGHVVLGDFPPILIYQIGEHETRILIDIPDNLPSASVANGGVKGHMRNVVLPSLPECIRPSFEAALEKGGFRSMPNSFLRPVTNRIPGLMFLGDSLNMRHPLTGGGMTVAFNDVVLLRNLLSPEAVPDLSDTKLVLKQLSKFHWQRKSLISVINILAQSLYSIFAAGDPNLKVLQRGCFRYFQLGLIDGPIGLLSGIIRSPLVLLRHFYSVAFLAIWLHLTSKPIYLLPLTLFECIIVF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue453

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT700503
EMBL· GenBank· DDBJ
QOQ37935.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700509
EMBL· GenBank· DDBJ
QOQ37941.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700519
EMBL· GenBank· DDBJ
QOQ37951.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700520
EMBL· GenBank· DDBJ
QOQ37952.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700521
EMBL· GenBank· DDBJ
QOQ37953.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700522
EMBL· GenBank· DDBJ
QOQ37954.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700525
EMBL· GenBank· DDBJ
QOQ37957.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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