A0A7M1IED8 · A0A7M1IED8_9EURO

Function

function

Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionsqualene monooxygenase activity
Biological Processergosterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Squalene monooxygenase
  • EC number

Gene names

    • Name
      erg1

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 205666/19
    • 205667/19
    • 209934/19
    • 211564/18
    • 216532/19
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Arthrodermataceae > Trichophyton

Accessions

  • Primary accession
    A0A7M1IED8

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Microsome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-39Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-51FAD dependent oxidoreductase
Domain172-446Squalene epoxidase

Sequence similarities

Belongs to the squalene monooxygenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    453
  • Mass (Da)
    49,934
  • Last updated
    2023-05-03 v1
  • Checksum
    B87AECDFC324FCDB
AKPKAYRDEAERRRYEHHEADVVIIGAGIAGCALAVALGNQGRSVILLERSLKEPDRIVGELLQPGGVRALEQLGLRDCLEGIDAVRTYGYDVIYFGNGVKIPFPSDANDKILEGRCFHHGRFIMRLREAAAANPNVTIVETKAVSTIKSTHTGDVLGVQCQTDGKQDFYFGPLTVVADGYASTFRKEYLPIQPVAKSKFWGLELIDAKLPIPGHGHVVLGDFPPILIYQIGEHETRILIDIPDNLPSASVANGGVKGHMRNVVLPSLPECIRPSFEAALEKGGFRSMPNSFLRPVTNRIPGLMFLGDSLNMRHPLTGGGMTVAFNDVVLLRNLLSPEAVPDLSDTKLVLKQLSKFHWQRKSLISVINILAQSLYSIFAAGDPNLKVLQRGCFRYFQLGLIDGPIGLLSGIIRSPLVLLRHFYSVAFLTIWLHLTSKPIYLLPLTLFECIIVF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue453

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT700502
EMBL· GenBank· DDBJ
QOQ37934.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700504
EMBL· GenBank· DDBJ
QOQ37936.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700506
EMBL· GenBank· DDBJ
QOQ37938.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700510
EMBL· GenBank· DDBJ
QOQ37942.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700511
EMBL· GenBank· DDBJ
QOQ37943.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700512
EMBL· GenBank· DDBJ
QOQ37944.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700514
EMBL· GenBank· DDBJ
QOQ37946.1
EMBL· GenBank· DDBJ
Genomic DNA
MT700517
EMBL· GenBank· DDBJ
QOQ37949.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp