A0A7M1C9K7 · A0A7M1C9K7_9TELE

Function

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear chromosome
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Molecular Functionmetal ion binding
Biological Processmeiotic DNA double-strand break formation
Biological Processmeiotic DNA double-strand break processing
Biological Processreciprocal meiotic recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase (ATP-hydrolyzing)
  • EC number

Gene names

    • Name
      spo11

Organism names

Accessions

  • Primary accession
    A0A7M1C9K7

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain97-157Spo11/DNA topoisomerase VI subunit A N-terminal
Domain206-377Topoisomerase 6 subunit A/Spo11 TOPRIM

Sequence similarities

Belongs to the TOP6A family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    383
  • Mass (Da)
    43,455
  • Last updated
    2021-04-07 v1
  • Checksum
    29484A15E99CA7AA
MADQFIVVDKLRDTLRESLEKDDRRQEDISRQDVLTRIERVIQTIVFSVSEGEAPVLRLMNRCNWASVRFHESVGLVRKADVPVTTLRCDCPSSATRFALIFKLLSVIYKLVQSDSYATKRDIYYNDPQLFGSQKTLDSILDDISCMLKVPRRSLHVFATSKGFISGDLCYLEEDGTKVDCNSSSTAVPVSSNVNGIRNTVSAAKFILIVEKDATFQRLLDDAFCTRLSPCIIITGKGVPDVNSRLMVRKLWDTLHIPVFALVDADPYGIEIICIYKYGSRSLAFEAHSLTVPSVLWLGLLPSDIQRYRVPEETLIPFSQADESKINSLRTRDYISCQPAWEREIEAMQRLKQKAEIQSLASIAPHFLTRVYLPNKLRYGGWI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MT648221
EMBL· GenBank· DDBJ
QOP60762.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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