A0A7L8AGL8 · A0A7L8AGL8_9FLAO

  • Protein
    Fumarate hydratase class II
  • Gene
    fumC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.

Miscellaneous

There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site99-101substrate
Binding site141-143substrate
Binding site189substrate
Active site190Proton donor/acceptor
Active site320
Binding site321substrate
Binding site326-328substrate
Site333Important for catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionfumarate hydratase activity
Biological Processfumarate metabolic process
Biological Processmalate metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fumarate hydratase class II
  • EC number
  • Short names
    Fumarase C
  • Alternative names
    • Aerobic fumarase
    • Iron-independent fumarase

Gene names

    • Name
      fumC
    • ORF names
      H9I45_01355

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • KCTC 52418
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae

Accessions

  • Primary accession
    A0A7L8AGL8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-344Fumarate lyase N-terminal
Domain410-463Fumarase C C-terminal

Sequence similarities

Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    466
  • Mass (Da)
    50,331
  • Last updated
    2021-09-29 v1
  • MD5 Checksum
    BCC1371B7A63BFC80F38A826F4C77D76
MTKFRIEKDTMGNVEVPADKYWGAQTERSRNNFKIGAPASMPLEIVYGFAYLKKAAAYTNTELGVLAEEKRDLIAQVCDEILEGKHDNQFPLVIWQTGSGTQSNMNVNEVIANRAHEIAGKVIGQGEKTIQPNDDVNKSQSSNDTFPTGMHIAIYKKIVETTMPGIIKLRNTLHDKAVAFKDVVKIGRTHLMDATPLTLGQEFSGYVAQLDFGLKALENTLAHLSQLALGGTAVGTGLNTPKGYDVLVAKYIAEFTELPFITAENKFEALAAHDALVETHGALKQIAVSLNKIANDIRLMASGPRSGIGEIIIPANEPGSSIMPGKVNPTQAEAITMVCAQVMGNDVAVTVGGTQGHYELNVFKPMMAANVLQSAQLIGDACTSFEENCAAGIEPNHTRIAELVSNSLMLVTALNTKIGYYKAAEIANTAHENGTTLKHEAVRLGYVTPEEYDAWVKPEEMTGGLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP061813
EMBL· GenBank· DDBJ
QOD61117.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help