A0A7L8AE77 · A0A7L8AE77_9FLAO
- ProteinDihydrolipoyl dehydrogenase
- GenelpdA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids466 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Miscellaneous
The active site is a redox-active disulfide bond.
Catalytic activity
- N6-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD+ = N6-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H+
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 50 | FAD (UniProtKB | ChEBI) | |||
Binding site | 114 | FAD (UniProtKB | ChEBI) | |||
Binding site | 143-145 | FAD (UniProtKB | ChEBI) | |||
Binding site | 180-187 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 203 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 271 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 312 | FAD (UniProtKB | ChEBI) | |||
Binding site | 318-321 | FAD (UniProtKB | ChEBI) | |||
Active site | 444 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dihydrolipoyl dehydrogenase activity | |
Molecular Function | flavin adenine dinucleotide binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrolipoyl dehydrogenase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae
Accessions
- Primary accessionA0A7L8AE77
Proteomes
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 41↔46 | Redox-active | |||
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-327 | FAD/NAD(P)-binding | |||
Domain | 346-455 | Pyridine nucleotide-disulphide oxidoreductase dimerisation | |||
Sequence similarities
Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length466
- Mass (Da)49,880
- Last updated2021-09-29 v1
- MD5 Checksum4F2FC9837CFBE03432D39BDAC37F3B72
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP061813 EMBL· GenBank· DDBJ | QOD60234.1 EMBL· GenBank· DDBJ | Genomic DNA |