A0A7L7SRR7 · A0A7L7SRR7_9CAUD
- ProteinNAD(+)--arginine ADP-ribosyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids697 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ADP-ribosyltransferase that efficiently ADP-ribosylates one of the two alpha subunits of host RNA polymerase RPOA on an arginine located in the C-terminal region. ADP-ribosylation of RPOA alpha subunit enhances the transcription of viral early genes. Also ribosylates RPOA subunits beta, beta' and sigma 70 and performs an autoribosylation reaction.
Catalytic activity
- L-arginyl-[protein] + NAD+ = H+ + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 6-7 | Cleavage | ||||
Sequence: EL | ||||||
Active site | 589 | |||||
Sequence: E | ||||||
Site | 632-633 | Cleavage | ||||
Sequence: ES |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | virion component | |
Molecular Function | NAD+-protein-arginine ADP-ribosyltransferase activity | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | regulation of viral transcription |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD(+)--arginine ADP-ribosyltransferase
- EC number
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Straboviridae > Tevenvirinae > Tequatrovirus > Tequatrovirus nbeco
Accessions
- Primary accessionA0A7L7SRR7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: About 25-50 copies per virion. This protein is injected into the bacterial cell along with the viral DNA.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_5042301661 | 1-697 | NAD+--arginine ADP-ribosyltransferase | |||
Sequence: MELITELFDEDTTLPITNLNPKKKIPQIFSVHVDDAIEQPGFRLCTYTSGGDTNRDLKMGDKMMHIVPFTLTAKGSIAKLKGLGPSPINYINSVFTVAMQTMRQYKIDACMLRILKSKTAGQARQIQVIADRLIRSRSGGRYVLLKELWDYDKKYAYILIHRKNVSLEDIPGVPEISTELFTKVESKVGDVYINKDTGAQVTKNEAIAASIAQENDKRSDQAVIVKVKISRRAIAQSQSLESSRFESELFQKYESTAANFNKPATAPLIPEAEEMKLGINSLASKTKAAKIIAEGTADELHYDYKFFLKSEVNEVSEKIKDVILNAIKNEPTTSIKCLEKYAAAVNQLFEEYKDNWLDKHNKTRKGQPDEVWEEITKNSWNAAKTKFLKRMIYSFSGIGAGPMIDITIARDGSKYTPSQKRGIREYCGSGYTDINNLLLGRYNPERYDVMSEKEIESAINNLDSAFENGDRIPEGITVYRAQSMTAPIYEALVKNKVFYFRNFVSTSLTPIIFGRFGITHAGIGLLEPEARNELTVDKNEEGITINPNEIRAYKENPEYVKVQIGWAIDGAHKVNVVYPGSLGIATEAEVILPRGLMVKVNKITDASNNDGTTSNNTKLIQAEVMTTEELTESVIYDGDHLMETGELAAMTGDIEIEDRVDFASFVSSNIKQKVESSLGIIASCIDITNMPYKFVQG |
Post-translational modification
Proteolytic cleavages at the N- and C-termini by the prohead core protein protease give rise to the mature enzyme.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 378-627 | ADP ribosyltransferase | ||||
Sequence: NSWNAAKTKFLKRMIYSFSGIGAGPMIDITIARDGSKYTPSQKRGIREYCGSGYTDINNLLLGRYNPERYDVMSEKEIESAINNLDSAFENGDRIPEGITVYRAQSMTAPIYEALVKNKVFYFRNFVSTSLTPIIFGRFGITHAGIGLLEPEARNELTVDKNEEGITINPNEIRAYKENPEYVKVQIGWAIDGAHKVNVVYPGSLGIATEAEVILPRGLMVKVNKITDASNNDGTTSNNTKLIQAEVMTT |
Sequence similarities
Belongs to the Tevenvirinae NAD(+)--arginine ADP-ribosyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length697
- Mass (Da)77,932
- Last updated2021-04-07 v1
- Checksum0A8F73E19CB8B933