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A0A7L5UF69 · A0A7L5UF69_9LACO

Function

function

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.
Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site51Zn2+ (UniProtKB | ChEBI); catalytic
Active site53Proton donor
Binding site77Zn2+ (UniProtKB | ChEBI); catalytic
Binding site86Zn2+ (UniProtKB | ChEBI); catalytic
Binding site156NADP+ (UniProtKB | ChEBI)
Binding site185substrate
Binding site197NADP+ (UniProtKB | ChEBI)
Binding site201NADP+ (UniProtKB | ChEBI)
Binding site205substrate
Binding site288substrate
Binding site290-296NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function5-amino-6-(5-phosphoribosylamino)uracil reductase activity
Molecular Functiondiaminohydroxyphosphoribosylaminopyrimidine deaminase activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Riboflavin biosynthesis protein RibD

Including 2 domains:

  • Recommended name
    Diaminohydroxyphosphoribosylaminopyrimidine deaminase
  • EC number
  • Short names
    DRAP deaminase
  • Alternative names
    • Riboflavin-specific deaminase
  • Recommended name
    5-amino-6-(5-phosphoribosylamino)uracil reductase
  • EC number
  • Alternative names
    • HTP reductase

Gene names

    • Name
      ribD
    • ORF names
      GTO83_00200

Organism names

  • Taxonomic identifier
  • Strain
    • 3B(2020)
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A7L5UF69

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-125CMP/dCMP-type deaminase

Sequence similarities

In the C-terminal section; belongs to the HTP reductase family.
In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    351
  • Mass (Da)
    38,579
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    CDA382E7FC1978E6396784FD0B1DA7D2
MNHDQAMMQLAINAAKEGRFLTWQNPMVGAAVVKDGHVLALGHHVKYGAVHAERNAIEKLTPEQLFNATLYVTLEPCNHQGKQPPCSELIIHSKIKRVVIGQTDPHALVTGKGIARLKTAGIEVITGVLADQATALNPFYTYFFQHHQPWITLKQAISLDHKLSLPGQRITLSSSAALKQVHFERANYQGILIGSETAIIDDPSLLTTVKSPFPPIRMIIDRRGRLLNHPNLKLLTDGAAPTWIFTQNNQLGNHQWPAHVKVISLADGQLSSVIDYLTDQGIQSLYVEGGRRLHQAFCDAGLGNELITYLAPVTLGKNGVPAYQPKAGQLIKPSYQFFGNTIRIQGGIQNV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP047410
EMBL· GenBank· DDBJ
QLL69106.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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