A0A7L5UF68 · A0A7L5UF68_9LACO
- ProteinATP-dependent helicase/nuclease subunit A
- GeneaddA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1270 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
Catalytic activity
- ATP + H2O = ADP + phosphate + H+
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 25-32 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | DNA helicase complex | |
Molecular Function | 3'-5' DNA helicase activity | |
Molecular Function | 3'-5' exonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | double-stranded DNA binding | |
Molecular Function | isomerase activity | |
Biological Process | double-strand break repair via homologous recombination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent helicase/nuclease subunit A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus
Accessions
- Primary accessionA0A7L5UF68
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Heterodimer of AddA and AddB/RexB.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-467 | UvrD-like helicase ATP-binding | |||
Domain | 495-821 | UvrD-like helicase C-terminal | |||
Sequence similarities
Belongs to the helicase family. AddA subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,270
- Mass (Da)144,562
- Last updated2021-04-07 v1
- MD5 Checksum5A8B17C65FEDA46FA3A063041BCE807A
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP047410 EMBL· GenBank· DDBJ | QLL69109.1 EMBL· GenBank· DDBJ | Genomic DNA |