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A0A7L5UF68 · A0A7L5UF68_9LACO

  • Protein
    ATP-dependent helicase/nuclease subunit A
  • Gene
    addA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site25-32ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentDNA helicase complex
Molecular Function3'-5' DNA helicase activity
Molecular Function3'-5' exonuclease activity
Molecular FunctionATP binding
Molecular Functiondouble-stranded DNA binding
Molecular Functionisomerase activity
Biological Processdouble-strand break repair via homologous recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent helicase/nuclease subunit A
  • EC number
  • Alternative names
    • ATP-dependent helicase/nuclease AddA
    • DNA 3'-5' helicase AddA

Gene names

    • Name
      addA
    • ORF names
      GTO83_00215

Organism names

  • Taxonomic identifier
  • Strain
    • 3B(2020)
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus

Accessions

  • Primary accession
    A0A7L5UF68

Proteomes

Subcellular Location

Interaction

Subunit

Heterodimer of AddA and AddB/RexB.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain4-467UvrD-like helicase ATP-binding
Domain495-821UvrD-like helicase C-terminal

Sequence similarities

Belongs to the helicase family. AddA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,270
  • Mass (Da)
    144,562
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    5A8B17C65FEDA46FA3A063041BCE807A
MAGFNPTPKQKQVITDQGKDILVSASAGSGKTAVLVRRVIQLLKTHPDLNIDQFLLVTFTKEAAKNMRDRIRSSLLAENNATLRKQLSRLPLANISTIHAFCEQVIKQYYYVIGLDPKYRLLTDDTEENLLRDQVWNDLQEEYLAKNGEFKRLKEAFQDPKSNVGEGLADVVIRLDEIANAQAHPNDWLKQLMVAYQVRPGALMESPFFQAYVLKAIFQELDQLRHALADLIDTIPNDPGFERALIAVQADSDQVEAIADQLEQGNWDAAVELVQNPKFKTWGTKGLDEADKALADDLKAQRDALKDQFKASLPKYLLASEAVMEKRIQIAATYLEQLVAVTQEFRQRYQGVKQAQHLLDFNDLEHYTYQILTTDSTEGRQAQGQLRHHYREIMVDEYQDTNGIQDELVKQLHDPKFNHLFMVGDVKQSIYRFRQADPTLFLDRYREYSGPATDNEAIVLAENFRSMESVTSFVNLVFTQLMDENLGEMAYDDDAQLKYAAKRYEAADEPRPATEMLLYNATEKDEVPDPAVEHYVERQVNDADAGEVWLIGMRIRQMLDRQELIYDQKTDQMRPIQPQDIAILARTKTLNNQIVEQFARLEIPVVVHDVKNYFKAIEVQTVLALLKIIDNPAQDIPLVTVLRSPMYGFTERELAFIRIHHRHDDFYAALIKVKGMLVETEQKTKLQAEWKAWEMEAPTEVGPKPTDFTTFAGKVITFLKQLGHFQQVAEQQALADLIWQIYQTTDYLDYVAAMPGGSQRQANLHAFYQRANEYEQGNFRGLYQFINFIERLQRRNDDLAQAPVEVVGDAVNVMTIHGSKGLQFPVVFLVNSSHQFNHQNQSAPIIVNPHDEMIGLRFSEPYQGDPVIRYRFDLPQREVVLQSLTKQERAEEMRLLYVALTRAEQRLIITAGIKQDPEKLITNWKAAANDPKLVLGTNVRLKAHSMLDWLGMTLCRTGLLSPAQFNSDEAWPTLPGLKTKAKLQFKIYTANQVEAELNALKAVRSDQALTTKKTSLSREERNFINQTMTMVYPYETATRTTAYQSVSAVKEVFANQDPDEAKMGHVTFNQQVAKEEGRYLRGEFGQPDFISAGPTTPSPTLVGTATHLVFQQLDLTKGEVTKGMVTTLIKHLVTSGLIESAQIAENVNVDGIVNFYQTELGQQILANPTAVEREKPFSMLLNGHNLFTNLHPEDGELLIHGIIDGYLTTPDGIIIFDYKTDELKSKGIQGIKDRYQGQVHLYADALHQMTGRPILKQYLYLVRIGELVEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP047410
EMBL· GenBank· DDBJ
QLL69109.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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