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A0A7L4P8Y8 · A0A7L4P8Y8_9CREN

Function

function

Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site152Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionmevalonate kinase activity
Biological Processisopentenyl diphosphate biosynthetic process, mevalonate pathway
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mevalonate kinase
  • EC number
  • Short names
    MK
    ; MVK

Gene names

    • Name
      mvk
    • ORF names
      HC235_03995

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 2GA
  • Taxonomic lineage
    Archaea > Thermoproteota > Thermoprotei > Thermoproteales > Thermoproteaceae > Pyrobaculum

Accessions

  • Primary accession
    A0A7L4P8Y8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain94-160GHMP kinase N-terminal
Domain226-300GHMP kinase C-terminal

Sequence similarities

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    315
  • Mass (Da)
    33,362
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    4FAE8ED5392E6C0E061A6D4FA75A7EF7
MKKSIFAPGVVKLFGEHAVVYGKPAIAAAIDKGVYIDCVSSDRLVVETVGITTGLRFSPLDRRVEAFGAEKFFAYVETALRLAQERWGDLAAKFTIRSDLPPSAGAATSAAVSVGILKAYALCAGADVGDEEAAKLGHKVELEVQGIASPMDTAAVTYGGVLKILTNPFRAEPLKIQLPPFYIVLLPRLGTTGEIVKDVRALLGKRKSATWVIEAIGKVVEEAEGCLRAGDLECVGELMDINNWLLGALGVVDGRVVDLLGMLKPFIYGGKISGAGRGGIVILIPKEGDVVSRILKGLGYPYYKVSVYPKGAGEV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAVJF010000002
EMBL· GenBank· DDBJ
NYR15123.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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