A0A7L3Z4J6 · A0A7L3Z4J6_FREGA
- ProteinDelta(14)-sterol reductase LBR
- GeneLbr
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids595 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.
Catalytic activity
- 4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
- 4,4-dimethyl-8,14-cholestadien-3beta-ol + NADPH + H+ = 4,4-dimethyl-5alpha-cholest-8-en-3beta-ol + NADP+
- 5alpha-cholest-8,14-dien-3beta-ol + NADPH + H+ = 5alpha-cholest-8-en-3beta-ol + NADP+
Pathway
Steroid biosynthesis; cholesterol biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | nuclear inner membrane | |
Molecular Function | delta14-sterol reductase activity | |
Molecular Function | DNA binding | |
Biological Process | cholesterol biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDelta(14)-sterol reductase LBR
- EC number
- Short namesC14SR ; Delta-14-SR
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Aequornithes > Procellariiformes > Hydrobatidae > Fregetta
Accessions
- Primary accessionA0A7L3Z4J6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Nucleus inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 207-229 | Helical | |||
Transmembrane | 254-273 | Helical | |||
Transmembrane | 294-313 | Helical | |||
Transmembrane | 325-344 | Helical | |||
Transmembrane | 365-386 | Helical | |||
Transmembrane | 398-416 | Helical | |||
Transmembrane | 436-456 | Helical | |||
Transmembrane | 462-481 | Helical | |||
Transmembrane | 502-523 | Helical | |||
Transmembrane | 543-562 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 4-62 | Tudor | |||
Region | 53-108 | Disordered | |||
Compositional bias | 61-84 | Polar residues | |||
Compositional bias | 94-108 | Basic and acidic residues | |||
Sequence similarities
Belongs to the ERG4/ERG24 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length595
- Mass (Da)68,761
- Last updated2021-04-07 v1
- MD5 Checksum41693429F500ABFF880AE0F183B3EDF0
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Compositional bias | 61-84 | Polar residues | |||
Compositional bias | 94-108 | Basic and acidic residues | |||
Non-terminal residue | 595 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VZZT01001965 EMBL· GenBank· DDBJ | NXW08587.1 EMBL· GenBank· DDBJ | Genomic DNA |