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A0A7L3Z4J6 · A0A7L3Z4J6_FREGA

Function

function

Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Steroid biosynthesis; cholesterol biosynthesis.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentnuclear inner membrane
Molecular Functiondelta14-sterol reductase activity
Molecular FunctionDNA binding
Biological Processcholesterol biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta(14)-sterol reductase LBR
  • EC number
  • Short names
    C14SR
    ; Delta-14-SR
  • Alternative names
    • 3-beta-hydroxysterol Delta (14)-reductase
    • C-14 sterol reductase
    • Integral nuclear envelope inner membrane protein
    • Lamin-B receptor
    • Sterol C14-reductase

Gene names

    • Name
      Lbr
    • ORF names
      FREGRA_R05781

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-006-09
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Aequornithes > Procellariiformes > Hydrobatidae > Fregetta

Accessions

  • Primary accession
    A0A7L3Z4J6

Proteomes

Subcellular Location

Cytoplasm
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Nucleus inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane207-229Helical
Transmembrane254-273Helical
Transmembrane294-313Helical
Transmembrane325-344Helical
Transmembrane365-386Helical
Transmembrane398-416Helical
Transmembrane436-456Helical
Transmembrane462-481Helical
Transmembrane502-523Helical
Transmembrane543-562Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain4-62Tudor
Region53-108Disordered
Compositional bias61-84Polar residues
Compositional bias94-108Basic and acidic residues

Sequence similarities

Belongs to the ERG4/ERG24 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    595
  • Mass (Da)
    68,761
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    41693429F500ABFF880AE0F183B3EDF0
MPNRRFADGEVVMGRWPGSVLYYEVQVTSYDDVSHLYTVKYKDGTELALKESDIRSQSSFKHRKSQSSSSSPSRRSTSRSRSRSPGRPAKGRRRSSSQSREHKDDKKKTIQETNLALLVLVFLFKPSENNTRRYNGEPDSTERNDTSCIILEEKLKPDLEIERVLEHYSLRPRKEEKKKEEIYSEKKIFESIKTIEKASSKTKELEFGGRIGTFTLIFFLPATVFYLLLMCKQEDPSLMNFPPPLPALESLWEARVFGVFLLWFFLQVLFYLLPVGKVVEGLPLPNGRKLQYRINGFYAFILTAAAIGTLLYFQFELHYLYDHFMQFAVSAAAFSMGLSIYLYIRSLKAPEEELAPGGNSGELRIFWKISFQLFATVIINLAMLLAEMKIHNQSMPSLSMILVNSFQLLYVVDALWNEEAILTTMDITHDGFGFMLAFGDLVWVPFVYSLQALYLVGHPTEISWPVAAAITILNCIGYYIFRSANSQKNNFRRNPADPKLAYLKFIPTATGKGLLVTGWWGFVRHPNYLGDIIMALAWSLPCGFNHILPYFYVIYFICLLVHREARDEHHCKQKYGLAWERYCQRVPYRIFPYIY

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias61-84Polar residues
Compositional bias94-108Basic and acidic residues
Non-terminal residue595

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VZZT01001965
EMBL· GenBank· DDBJ
NXW08587.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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