A0A7L3DBK8 · A0A7L3DBK8_PLUSO
- ProteinUbiquitin-conjugating enzyme E2 B
- GeneUbe2b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids138 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. May play a role in DNA repair. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation. May be involved in neurite outgrowth.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 74 | Glycyl thioester intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | HULC complex | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | ubiquitin conjugating enzyme activity | |
Biological Process | DNA repair | |
Biological Process | proteasome-mediated ubiquitin-dependent protein catabolic process | |
Biological Process | protein polyubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin-conjugating enzyme E2 B
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Charadriidae > Pluvianellus
Accessions
- Primary accessionA0A7L3DBK8
Proteomes
Subcellular Location
Interaction
Subunit
Interacts with RAD18, UBR2 and WAC.
Structure
Sequence
- Sequence statusFragment
- Length138
- Mass (Da)15,565
- Last updated2021-04-07 v1
- MD5 ChecksumE6A3614ED88A28BCA3B5D44A1DF337CC
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 138 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VZTS01018130 EMBL· GenBank· DDBJ | NXT53526.1 EMBL· GenBank· DDBJ | Genomic DNA |