A0A7L3DBK8 · A0A7L3DBK8_PLUSO

Function

function

E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. May play a role in DNA repair. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation. May be involved in neurite outgrowth.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
    EC:2.3.2.23 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site74Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular ComponentHULC complex
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionubiquitin conjugating enzyme activity
Biological ProcessDNA repair
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein polyubiquitination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin-conjugating enzyme E2 B
  • EC number
  • Alternative names
    • E2 ubiquitin-conjugating enzyme B
    • Ubiquitin carrier protein B
    • Ubiquitin-protein ligase B

Gene names

    • Name
      Ube2b
    • ORF names
      PLUSOC_R09466

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-012-14
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Charadriiformes > Charadriidae > Pluvianellus

Accessions

  • Primary accession
    A0A7L3DBK8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Interacts with RAD18, UBR2 and WAC.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-136UBC core

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    138
  • Mass (Da)
    15,565
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    E6A3614ED88A28BCA3B5D44A1DF337CC
RLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue138

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VZTS01018130
EMBL· GenBank· DDBJ
NXT53526.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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