A0A7L2W6D2 · A0A7L2W6D2_PANHA
- ProteinCytosolic purine 5'-nucleotidase
- GeneNt5c2_0
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids566 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- AMP + inosine = adenosine + IMP
- CMP + inosine = cytidine + IMP
- GMP + H2O = guanosine + phosphateThis reaction proceeds in the forward direction.
- GMP + inosine = guanosine + IMP
- H2O + XMP = phosphate + xanthosineThis reaction proceeds in the forward direction.
- dGMP + H2O = 2'-deoxyguanosine + phosphateThis reaction proceeds in the forward direction.
- dGMP + inosine = 2'-deoxyguanosine + IMP
- dIMP + H2O = 2'-deoxyinosine + phosphateThis reaction proceeds in the forward direction.
- dIMP + inosine = 2'-deoxyinosine + IMP
- inosine + UMP = IMP + uridine
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 5'-nucleotidase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | transferase activity | |
Biological Process | adenosine metabolic process | |
Biological Process | GMP metabolic process | |
Biological Process | IMP metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytosolic purine 5'-nucleotidase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Accipitriformes > Pandionidae > Pandion
Accessions
- Primary accessionA0A7L2W6D2
Proteomes
Subcellular Location
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 494-566 | Disordered | ||||
Sequence: HVDINEKESPMATRNRTSVDFKDSDYKRHQLTRSISEIKPPNLFPQAPQEITHCHDEDDDEEEEEEEEEEEEE | ||||||
Compositional bias | 511-527 | Basic and acidic residues | ||||
Sequence: SVDFKDSDYKRHQLTRS | ||||||
Compositional bias | 548-566 | Acidic residues | ||||
Sequence: HDEDDDEEEEEEEEEEEEE |
Sequence similarities
Belongs to the 5'(3')-deoxyribonucleotidase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length566
- Mass (Da)65,537
- Last updated2021-04-07 v1
- Checksum2625879CB6C05AA5
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 511-527 | Basic and acidic residues | ||||
Sequence: SVDFKDSDYKRHQLTRS | ||||||
Compositional bias | 548-566 | Acidic residues | ||||
Sequence: HDEDDDEEEEEEEEEEEEE | ||||||
Non-terminal residue | 566 | |||||
Sequence: E |
Keywords
- Technical term