A0A7L1UN52 · A0A7L1UN52_PHANI

Function

function

Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenttranscription factor TFIIK complex
Molecular Functioncyclin-dependent protein serine/threonine kinase regulator activity
Biological ProcessDNA-templated transcription
Biological Processregulation of cyclin-dependent protein serine/threonine kinase activity
Biological Processregulation of transcription by RNA polymerase II

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Recommended name
    Cyclin-H

Gene names

    • Name
      Ccnh
    • ORF names
      PHANIT_R07138

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-002-32
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Bombycillidae > Phainopepla

Accessions

  • Primary accession
    A0A7L1UN52

Proteomes

Subcellular Location

Interaction

Subunit

Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-78Cyclin N-terminal
Domain82-172Cyclin C-terminal

Sequence similarities

Belongs to the cyclin family. Cyclin C subfamily.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    173
  • Mass (Da)
    19,867
  • Last updated
    2021-04-07 v1
  • Checksum
    468A1D737F90D5DC
GTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSAQFVGNLRESPVGQEKALEQILEYELLLIQQLNFHLIIHNPYRPFEGFLIDIKTRYPVLENPEVLRKTADDFLNRVALTDAYLLFTPSQIALTAILSSGSRAGINMESYLSESLMLKENRSSLSRLLDDMK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue173

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VXBQ01017513
EMBL· GenBank· DDBJ
NXO74311.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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