A0A7L0U807 · A0A7L0U807_CHOAC

Function

function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T3 and T4.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

heme b (UniProtKB | Rhea| CHEBI:60344 )

Pathway

Hormone biosynthesis; thyroid hormone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site434Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionheme binding
Molecular Functioniodide peroxidase activity
Biological Processhormone biosynthetic process
Biological Processhydrogen peroxide catabolic process
Biological Processresponse to oxidative stress
Biological Processthyroid hormone generation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thyroid peroxidase
  • EC number

Gene names

    • Name
      Tpo
    • ORF names
      CHOACU_R11792

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-008-62
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Strisores > Caprimulgiformes > Caprimulgidae > Chordeilinae > Chordeiles

Accessions

  • Primary accession
    A0A7L0U807

Proteomes

Subcellular Location

Membrane
; Single-pass type I membrane protein

PTM/Processing

Keywords

Interaction

Subunit

Interacts with DUOX1, DUOX2 and CYBA.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain680-736Sushi
Domain736-779EGF-like

Sequence similarities

Belongs to the prostaglandin G/H synthase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    787
  • Mass (Da)
    88,466
  • Last updated
    2021-04-07 v1
  • Checksum
    FCB02AE0D9735C0E
RNIQGRGIATPTLLLAFSKFPEPESRDISQAAERMEMSIQVLKQKVCQKHKRSLHSTDFLSADLLTMIANISGCLPYMLPPKCPNNCLANKYRLITGACNNREHPRWGASNTALARWLPPAYEDGLSQPRGWDPSVQYNGVQLPLVREVTRKIIHASNEAVTEDNLYSDIIMVWGQYIDHDIAFTPQSTSRTTFLNGMECQMTCEKQNPCFPIKVTTNDTLSAGMNCLPFYRSSPACSTGDHGTLFGNLSALNPRQQINGLTSFLDASTVYGSTPAIENKLRNLTSEEGLLRVNMKYYDNHREYLPFTDKIPSPCAQDLNASGEERIECFMAGDSRSSEVTSLAAMHTLWLREHNRLARALKNINGHWTAETVYQEARKIVGALHQIITLRDYIPKIIGPDAFSLYIGLYTGYDPTMNPTVSNVFSTAAFRFGHATIQPIVRRLNAQYLYDPELPNLHLHEVFFSPWRLIKEGGLDPLLRGLLAHSAKLQVPDQLLNEELTEKLFVLSNNGSLDLASLNLQRGRDHGLPGYNDWREFCGLPKLETQNDLNTVITNHNVTEKIMELYHNPSNIDVWLGGLVEDFLPGARTGPLFACIIGKQMKALRDGDRFWWENDNVFTEAQRHELEKHSFSRVICDNTGIAEVPADAFQLGKFPQDFKHCDNIPGMNLEAWQEFYQEEELCGTPKSVENGDFVYCSEFGKSTVTYSCQYGFQLQGEQQLTCTSKGWNFEAPVCIDINECENEINPPCSPSAECVNTKGSYKCLCTDPYKLAEDGRTCIGNACEPTV

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue787

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VXAQ01000674
EMBL· GenBank· DDBJ
NXL63164.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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