A0A7L0DFT7 · A0A7L0DFT7_9CHAR
- Proteincholesterol 7-desaturase
- GeneDaf36
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids419 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- cholesterol + H+ + NADH + O2 = 7-dehydrocholesterol + 2 H2O + NAD+This reaction proceeds in the forward direction.
Cofactor
Pathway
Hormone biosynthesis.
Steroid hormone biosynthesis; dafachronic acid biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | 2 iron, 2 sulfur cluster binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Biological Process | cholesterol metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namecholesterol 7-desaturase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Rostratulidae > Rostratula
Accessions
- Primary accessionA0A7L0DFT7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-40 | Helical | ||||
Sequence: LLFLLLILLLLVLLLLGCSRPLV |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 83-186 | Rieske | ||||
Sequence: YRLLDSAQLPRGAVRSLALLGEQLAVFRTQDGQAYVVGAFCPHLGANLAAGGRVVGSCIECPFHGWEFRGEDGKCTRIPYAEKVPDFAKVRTWPSCEVNGMLLV |
Sequence similarities
Belongs to the cholesterol 7-desaturase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length419
- Mass (Da)47,093
- Last updated2021-04-07 v1
- Checksum844A87D954CADA67
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 419 | |||||
Sequence: W |
Keywords
- Technical term