A0A7K9XDZ2 · A0A7K9XDZ2_9GRUI

Function

function

Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = 2,3-di-(9Z)-octadecenoyl-sn-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = di-(9Z)-octadecenoylglycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2,3-tributanoylglycerol + H2O = dibutanoylglycerol + butanoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = 2-(9Z-octadecenoyl)-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = hexadecanoyl-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = 3-(9Z-octadecenoyl)-sn-glycerol + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = sn-glycero-3-phospho-L-serine + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 2-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    EC:3.1.1.32 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H+
    EC:3.1.1.5 (UniProtKB | ENZYME | Rhea)
  • a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H+
    EC:3.1.1.3 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site139Nucleophile
Active site165Charge relay system
Binding site179Ca2+ (UniProtKB | ChEBI)
Binding site184Ca2+ (UniProtKB | ChEBI)
Active site250Charge relay system

GO annotations

AspectTerm
Cellular Componenthigh-density lipoprotein particle
Molecular Function1-acyl-2-lysophosphatidylserine acylhydrolase activity
Molecular Functionapolipoprotein binding
Molecular Functionheparin binding
Molecular Functionlipoprotein lipase activity
Molecular Functionlysophospholipase activity
Molecular Functionmetal ion binding
Molecular Functionphosphatidylserine 1-acylhydrolase activity
Molecular Functionphospholipase A1 activity
Biological Processfatty acid biosynthetic process
Biological Processtriglyceride catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hepatic triacylglycerol lipase
  • EC number
  • Alternative names
    • Lipase member C
    • Lysophospholipase
    • Phospholipase A1

Gene names

    • Name
      Lipc
    • ORF names
      PSOCRE_R10906

Organism names

  • Taxonomic identifier
  • Strain
    • B10K-DU-001-60
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Gruiformes > Psophiidae > Psophia

Accessions

  • Primary accession
    A0A7K9XDZ2

Proteomes

Subcellular Location

Keywords

  • Cellular component

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain323-458PLAT

Sequence similarities

Belongs to the AB hydrolase superfamily. Lipase family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    469
  • Mass (Da)
    53,681
  • Last updated
    2021-04-07 v1
  • Checksum
    787F710EFC7031CF
EALGSQSQHSRTKKDQQNLATKFRLYTDTTEGRCQIFLNQLETLEKCSFNASLPLVMIVHGWSVDGMLEDWIWKMAAALKSQHKQINVVIADWLTFAHQHYPIAVQNTRYIGQEIADFLEWLEESIQFSRSNAHLIGYSLGAHVSGFAGSYISGTTKIGRITGLDPAGPLFEGMSPTDRLSPDDANFVDAIHTFTKQHMGLSVGIKQPVAHFDFYPNGGTFQPGCHIMHVYNHIAQYGITGITQTVKCAHERSVHLFIDSLLHKDKQSTAYWCNDINTFNKGMCLSCRKNRCNTLGYNIREERLPKSRQLFLKTRAHMPFKVYHYQFKIHFINEIHGKQTDPTFTISLTGTKEDAKNLPITLFEGINGNKTYSFLITLDTDIGELIMMKFKWEGTAVWENIWDTVQTIIPWTKGTRRPGLIVKTIRVKAGETQQKMTFCSQSIDNIHLHPAQEKTFVRCEDRFRRQDRK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue469

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VWZZ01003624
EMBL· GenBank· DDBJ
NXI95063.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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