A0A7K9X6B4 · A0A7K9X6B4_9GRUI
- ProteinHedgehog protein
- GeneShh
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids425 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN. Both activities occur in the reticulum endoplasmic. Once cleaved, ShhC is degraded in the endoplasmic reticulum.
Protein hedgehog N-product
The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.
Protein hedgehog
The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.
Catalytic activity
- glycyl-L-cysteinyl-[protein] + cholesterol + H+ = [protein]-C-terminal glycyl cholesterol ester + N-terminal L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 92 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 93 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 93 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 98 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 128 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 129 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 129 | Ca2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 132 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 134 | Ca2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 143 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 150 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 185 | Zn2+ (UniProtKB | ChEBI) | |||
Site | 200-201 | Cleavage; by autolysis | |||
Site | 246 | Involved in cholesterol transfer | |||
Site | 270 | Involved in auto-cleavage | |||
Site | 273 | Essential for auto-cleavage | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | extracellular space | |
Cellular Component | Golgi membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | patched binding | |
Molecular Function | peptidase activity | |
Molecular Function | transferase activity | |
Biological Process | animal organ development | |
Biological Process | cell development | |
Biological Process | cell fate specification | |
Biological Process | cell-cell signaling | |
Biological Process | intein-mediated protein splicing | |
Biological Process | neuron differentiation | |
Biological Process | oligodendrocyte differentiation | |
Biological Process | pattern specification process | |
Biological Process | protein autoprocessing | |
Biological Process | regulation of cell population proliferation | |
Biological Process | regulation of developmental process | |
Biological Process | regulation of gene expression | |
Biological Process | smoothened signaling pathway | |
Biological Process | tissue development | |
Biological Process | tube development |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameHedgehog protein
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Gruiformes > Psophiidae > Psophia
Accessions
- Primary accessionA0A7K9X6B4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-26 | ||||
Chain | PRO_5029675991 | 27-425 | Hedgehog protein | ||
Keywords
- PTM
Interaction
Subunit
Multimer.
Structure
Sequence
- Sequence statusFragment
- Length425
- Mass (Da)46,572
- Last updated2021-04-07 v1
- ChecksumAF755EAA68F51E94
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 425 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VWZZ01002220 EMBL· GenBank· DDBJ | NXI92852.1 EMBL· GenBank· DDBJ | Genomic DNA |