A0A7K7D3X6 · A0A7K7D3X6_PHEME

Function

function

Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum
Cellular Componentmembrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNADP binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase 1
  • EC number
  • Alternative names
    • Dimethylaniline monooxygenase [N-oxide-forming] 1
    • Dimethylaniline oxidase 1
    • Trimethylamine monooxygenase

Gene names

    • Name
      Fmo1
    • ORF names
      PHEMEL_R06575

Organism names

Accessions

  • Primary accession
    A0A7K7D3X6

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane514-533Helical

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region398-422Disordered

Sequence similarities

Belongs to the FMO family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    534
  • Mass (Da)
    59,755
  • Last updated
    2021-04-07 v1
  • Checksum
    31E7E06BE8E6A5B5
TGMRVAVVGAGVSGLAATKCCLDEGLEPTCFEQSQDIGGLWRYTEHIEAGRPSLYPSVISNTSKEMSAFSDFPFPEHFPVFLPNALLLDYLRRYTEHFSLREHIRFGSTVVSIRKHPDFATTGQWDVVTEAGGKQTSHVFDAVMVCSGSFSEPSLPLQCFPGIERFRGQYFHSRQYKHPDVFQGKRVLVVGMGNSGVDIAVEASRVAAKVTISTTRGAWLLSRVFEHGYPWDMILNTRLMSLIKTNLPGPLSWWLTNYKVNQWFNHENYGLQPDNRYFLPLVNDELPSYILTGRITIKPGVKEFKDNSVLFHNCPEEEPIDIVVFCTGYSISFPFLEESIIRVENKHASLYKYVFPPQLQKPTLAVLGLIKPFGAIMPVVEMQARWVSRVFKGRGAHVSPPAPQNAAQPKLDMFRPSSQGDPRAKKFRVLKTEWLLYLDTLASFIGAKPSVLGLLCTDPRLALTIFFGPCSPYQYRLGGPGHWQGARQAILTQWDRVLKPTRTRVPAGSSSSSLSLLTVVGFLLLLAAVIFGFL

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue534

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
VZSJ01001418
EMBL· GenBank· DDBJ
NWY27745.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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