A0A7K6XFY4 · A0A7K6XFY4_9PASE
- Proteinreceptor protein-tyrosine kinase
- GeneTek
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1114 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 821-828 | ATP (UniProtKB | ChEBI) | |||
Binding site | 845 | ATP (UniProtKB | ChEBI) | |||
Active site | 954 | Proton acceptor | |||
Binding site | 958 | ATP (UniProtKB | ChEBI) | |||
Binding site | 959 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 972 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | angiogenesis | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | endothelial cell proliferation | |
Biological Process | positive regulation of angiogenesis | |
Biological Process | positive regulation of endothelial cell migration | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of MAPK cascade | |
Biological Process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namereceptor protein-tyrosine kinase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Nectariniidae > Promerops
Accessions
- Primary accessionA0A7K6XFY4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 736-760 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 229↔238 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 203-239 | EGF-like | |||
Domain | 337-427 | Ig-like | |||
Domain | 434-528 | Fibronectin type-III | |||
Domain | 532-626 | Fibronectin type-III | |||
Domain | 631-724 | Fibronectin type-III | |||
Domain | 814-1086 | Protein kinase | |||
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,114
- Mass (Da)124,725
- Last updated2021-04-07 v1
- MD5 Checksum2AE9FC0989ED9333BBE2F2DD58007ED6
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 1114 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
VZSE01005875 EMBL· GenBank· DDBJ | NWX58194.1 EMBL· GenBank· DDBJ | Genomic DNA |