A0A7K6X7J4 · A0A7K6X7J4_9PASE
- ProteinPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- GenePten
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids376 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphateThis reaction proceeds in the forward direction.
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphateThis reaction proceeds in the forward direction.
- 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + phosphateThis reaction proceeds in the forward direction.
- 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + phosphateThis reaction proceeds in the forward direction.
Cofactor
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 97 | Phosphocysteine intermediate | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | dendritic spine | |
Cellular Component | plasma membrane | |
Cellular Component | PML body | |
Cellular Component | postsynaptic density | |
Molecular Function | inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity | |
Molecular Function | protein tyrosine phosphatase activity | |
Biological Process | apoptotic process | |
Biological Process | cell motility | |
Biological Process | negative regulation of cell population proliferation | |
Biological Process | nervous system development | |
Biological Process | phosphatidylinositol dephosphorylation | |
Biological Process | protein dephosphorylation | |
Biological Process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Neoaves > Telluraves > Australaves > Passeriformes > Passeroidea > Nectariniidae > Promerops
Accessions
- Primary accessionA0A7K6X7J4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-158 | Phosphatase tensin-type | ||||
Sequence: IYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLRAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNH | ||||||
Domain | 75-146 | Tyrosine specific protein phosphatases | ||||
Sequence: KPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLRAQEALDFYGEVRTRDKKGVTIPSQRR | ||||||
Domain | 163-323 | C2 tensin-type | ||||
Sequence: PVALLFHKMMFETIPMFSSGTCNPQFVVYQLKVKIFTSPSGPSRREDKYMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIGLDENSDKVENGSLVADQELDGIFSTERSDNDKEYLILTLTKNDLDKANKDKANRYFSPNFKVKLFFTKT | ||||||
Compositional bias | 326-343 | Polar residues | ||||
Sequence: EPSNPEASSSTSVTPDVS | ||||||
Region | 326-376 | Disordered | ||||
Sequence: EPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV | ||||||
Compositional bias | 344-358 | Basic and acidic residues | ||||
Sequence: DNEPDHYRYSDTTDS |
Sequence similarities
Belongs to the PTEN phosphatase protein family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length376
- Mass (Da)43,997
- Last updated2021-04-07 v1
- Checksum17417081F170CB76
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: I | ||||||
Compositional bias | 326-343 | Polar residues | ||||
Sequence: EPSNPEASSSTSVTPDVS | ||||||
Compositional bias | 344-358 | Basic and acidic residues | ||||
Sequence: DNEPDHYRYSDTTDS | ||||||
Non-terminal residue | 376 | |||||
Sequence: V |
Keywords
- Technical term