A0A7K6DVE4 · A0A7K6DVE4_9PASS
- ProteinATP-binding cassette sub-family B member 6
- GeneAbcb6
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids840 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O + heme b(in) = ADP + H+ + heme b(out) + phosphateThis reaction proceeds in the forward direction.
CHEBI:30616 + CHEBI:15377 + heme b (in)CHEBI:60344= CHEBI:456216 + CHEBI:15378 + heme b (out)CHEBI:60344+ CHEBI:43474 - ATP + H2O + pheophorbide a(in) = ADP + H+ + pheophorbide a(out) + phosphateThis reaction proceeds in the forward direction.
- ATP + H2O + protoporphyrin IX(in) = ADP + H+ + phosphate + protoporphyrin IX(out)This reaction proceeds in the forward direction.
- ATP + H2O + uroporphyrin I(in) = ADP + H+ + phosphate + uroporphyrin I(out)This reaction proceeds in the forward direction.
- ATP + H2O + uroporphyrin III(in) = ADP + H+ + phosphate + uroporphyrin III(out)This reaction proceeds in the forward direction.
- ATP + coproporphyrin I(in) + H2O = ADP + coproporphyrin I(out) + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + coproporphyrin III(in) + H2O = ADP + coproporphyrin III(out) + H+ + phosphateThis reaction proceeds in the forward direction.
- ATP + coproporphyrinogen III(in) + H2O = ADP + coproporphyrinogen III(out) + H+ + phosphateThis reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | extracellular region | |
Cellular Component | Golgi membrane | |
Cellular Component | lysosomal membrane | |
Cellular Component | melanosome membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | multivesicular body membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-binding cassette sub-family B member 6
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Meliphagoidea > Acanthizidae > Origma
Accessions
- Primary accessionA0A7K6DVE4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 27-52 | Helical | ||||
Sequence: FFFTLVPSVLLSVCLLLGALQYACYA | ||||||
Transmembrane | 73-92 | Helical | ||||
Sequence: VLLSLLLALQPFGGLLWQGV | ||||||
Transmembrane | 98-119 | Helical | ||||
Sequence: YGYMLLHACLWALSWGCAIALL | ||||||
Transmembrane | 140-163 | Helical | ||||
Sequence: LLFWALAFAAENLTLVCWRSPLWW | ||||||
Transmembrane | 175-193 | Helical | ||||
Sequence: FGFWLLRYICTFMLFILGM | ||||||
Transmembrane | 375-397 | Helical | ||||
Sequence: LLSYIIFSIIPTIADIIIGIVYF | ||||||
Transmembrane | 403-424 | Helical | ||||
Sequence: AWFGLIIFVCMSLYLTLTIFIT | ||||||
Transmembrane | 495-513 | Helical | ||||
Sequence: LVIGLGLLAGSLLCAYFVT | ||||||
Transmembrane | 519-539 | Helical | ||||
Sequence: VGDFVLFGTYIIQLYTPLNWF |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 258-548 | ABC transmembrane type-1 | ||||
Sequence: LFCMALMGLERAINVFVPIYYKNIVNELTVGAPWHTLAWTVCSYVGLKFLQGGGAGSTGFVSNLRTFLWVWVQQFTNRQVQVQLFAHLHGLSLRWHLGRRTGEVLRSVDRGTSSINSLLSYIIFSIIPTIADIIIGIVYFTSVFSAWFGLIIFVCMSLYLTLTIFITEWRTKYRRDMNTRDNEAKSRAVDSLLNFETVKYYNAESYEVNRFNDAIVKYQVSEWKVSASLGLLNQTQNLVIGLGLLAGSLLCAYFVTENKLQVGDFVLFGTYIIQLYTPLNWFGTYYRMIQN | ||||||
Domain | 582-816 | ABC transporter | ||||
Sequence: IEFENVHFSYVDGKEILQDVSFSVMPGQTLALVGPSGSGKSTIIRLLFRFYDVGGGCIRIDGQDISQVKQASLRAHIGVVPQDTVLFNDTIANNIRYGRILATDQEVQEAARAADIHDRILSFPDGYNTQVGERGLKLSGGEKQRVAIARTILKGPHIILLDEATSALDTETERNIQASLAKVCAHRTTIVVAHRLSTVVGADQILVLKDGHIMERGRHEELLQKGGVYAGMWLQ | ||||||
Region | 816-840 | Disordered | ||||
Sequence: QQQTGDEGESKERHTEKPQGSKKGS | ||||||
Compositional bias | 821-840 | Basic and acidic residues | ||||
Sequence: DEGESKERHTEKPQGSKKGS |
Sequence similarities
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length840
- Mass (Da)95,048
- Last updated2021-04-07 v1
- Checksum859EBCD6BBFC2045
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 821-840 | Basic and acidic residues | ||||
Sequence: DEGESKERHTEKPQGSKKGS | ||||||
Non-terminal residue | 840 | |||||
Sequence: S |
Keywords
- Technical term