A0A7K5NHR3 · A0A7K5NHR3_CHRMC
- ProteinHepatic triacylglycerol lipase
- GeneLipc
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids469 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 2,3-di-(9Z)-octadecenoyl-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1,2,3-tri-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + di-(9Z)-octadecenoylglycerol + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H+This reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycerol + H2O = (9Z)-octadecenoate + 2-(9Z-octadecenoyl)-glycerol + H+This reaction proceeds in the forward direction.
- 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + hexadecanoyl-sn-glycero-3-phosphocholineThis reaction proceeds in the forward direction.
- 1,3-di-(9Z-octadecenoyl)-glycerol + H2O = (9Z)-octadecenoate + 3-(9Z-octadecenoyl)-sn-glycerol + H+This reaction proceeds in the forward direction.
- 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + H2O = (9Z)-octadecenoate + H+ + sn-glycero-3-phospho-L-serineThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = H+ + hexadecanoate + sn-glycerol 3-phosphocholineThis reaction proceeds in the forward direction.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | high-density lipoprotein particle | |
Molecular Function | 1-acyl-2-lysophosphatidylserine acylhydrolase activity | |
Molecular Function | heparin binding | |
Molecular Function | lysophospholipase activity | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatidylserine 1-acylhydrolase activity | |
Molecular Function | phospholipase A1 activity | |
Molecular Function | triglyceride lipase activity | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHepatic triacylglycerol lipase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Laridae > Chroicocephalus
Accessions
- Primary accessionA0A7K5NHR3
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 323-458 | PLAT | ||||
Sequence: YHYQFKIHFINEIQDKQIDPTFTISLTGTKEDAKNLPIPLVEGISGNKTYSFLLTLDTDIGELIMIKFKWEGTAVWENIWDTVQTIIPWTKGTRRPGLIVKTIRVKAGETQQKMTFCSQSIDNVHLHPAQEKTFVR |
Sequence similarities
Belongs to the AB hydrolase superfamily. Lipase family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length469
- Mass (Da)53,588
- Last updated2021-04-07 v1
- Checksum2877A3EF8573859D
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: E | ||||||
Non-terminal residue | 469 | |||||
Sequence: K |