A0A7K5N143 · A0A7K5N143_CHRMC
- ProteinNon-selective voltage-gated ion channel VDAC1
- GeneVdac1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids285 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids.
Catalytic activity
- ATP(in) = ATP(out)
- Ca2+(in) = Ca2+(out)
- Fe(III)-[cytochrome c](out) = Fe(III)-[cytochrome c](in)
- K+(in) = K+(out)
- L-glutamate(out) = L-glutamate(in)
- Mg2+(in) = Mg2+(out)
- Na+(in) = Na+(out)
- acetylcholine(in) = acetylcholine(out)
- chloride(in) = chloride(out)
- dopamine(out) = dopamine(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane raft | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | plasma membrane | |
Cellular Component | pore complex | |
Molecular Function | porin activity | |
Molecular Function | voltage-gated monoatomic anion channel activity | |
Biological Process | apoptotic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameNon-selective voltage-gated ion channel VDAC1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Charadriiformes > Laridae > Chroicocephalus
Accessions
- Primary accessionA0A7K5N143
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane raft ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Sequence
- Sequence statusFragment
- Length285
- Mass (Da)30,891
- Last updated2021-04-07 v1
- Checksum501FF47220D3DDC3
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: Q | ||||||
Non-terminal residue | 285 | |||||
Sequence: A |