A0A7K5CRK7 · A0A7K5CRK7_9TYRA
- ProteinMyotubularin
- GeneMtm1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids603 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 313-314 | substrate | ||||
Sequence: NI | ||||||
Active site | 375 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 375-381 | substrate | ||||
Sequence: CSDGWDR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | filopodium | |
Cellular Component | late endosome | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Cellular Component | sarcomere | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Molecular Function | phosphoprotein phosphatase activity | |
Biological Process | lipid metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMyotubularin
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Archelosauria > Archosauria > Dinosauria > Saurischia > Theropoda > Coelurosauria > Aves > Neognathae > Passeriformes > Tyrannidae > Pachyramphus
Accessions
- Primary accessionA0A7K5CRK7
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-25 | Polar residues | ||||
Sequence: MASSSTPKYNSNSLESSSSKRTLKD | ||||||
Region | 1-40 | Disordered | ||||
Sequence: MASSSTPKYNSNSLESSSSKRTLKDGTNWEQNEEIPRLPG | ||||||
Compositional bias | 26-40 | Basic and acidic residues | ||||
Sequence: GTNWEQNEEIPRLPG | ||||||
Domain | 163-538 | Myotubularin phosphatase | ||||
Sequence: GWMVYNPMSEYRRQGLPNDRWRVTFINEHYGLCDTYPSLLVVPYNATDEDLKKVAAFRSRNRIPVLSWIHPETQAVIMRCSQPLVGMSGKRNKDDERYLDIIREANGQISKLTIYDARPNVNAVANKATGGGYEGEDAYPNAELFFLDIHNIHVMRESLKKLKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGRSSVLVHCSDGWDRTAQLTSLAMLMLDSYYRTIEGFEVLVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLITILDHLYSCRFGTFLYNSESVREKEKVAEKTLSLWSLINSEKSKYTNPFYSKELNRALYPVASMRHLELWVNYY | ||||||
Domain | 344-406 | Tyrosine specific protein phosphatases | ||||
Sequence: THWLEHIKLVLTGAIQVADKVSSGRSSVLVHCSDGWDRTAQLTSLAMLMLDSYYRTIEGFEVL | ||||||
Region | 579-603 | Disordered | ||||
Sequence: NSKIPNSSASSTSPSQMMSQVQTHF |
Sequence similarities
Family and domain databases
Sequence
- Sequence statusFragment
- Length603
- Mass (Da)69,751
- Last updated2021-04-07 v1
- ChecksumE86520F15E674C58
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: M | ||||||
Compositional bias | 1-25 | Polar residues | ||||
Sequence: MASSSTPKYNSNSLESSSSKRTLKD | ||||||
Compositional bias | 26-40 | Basic and acidic residues | ||||
Sequence: GTNWEQNEEIPRLPG | ||||||
Non-terminal residue | 603 | |||||
Sequence: F |
Keywords
- Technical term