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A0A7K4AJ78 · A0A7K4AJ78_METSH

Function

function

Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site49-51L-glutamine (UniProtKB | ChEBI)
Active site81Nucleophile
Binding site109L-glutamine (UniProtKB | ChEBI)
Binding site137-138L-glutamine (UniProtKB | ChEBI)
Active site173
Active site173Charge relay system
Active site175
Active site175Charge relay system

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentglutaminase complex
Molecular Functionglutaminase activity
Molecular Functionpyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
Biological Processglutamine catabolic process
Biological Processpyridoxal phosphate biosynthetic process
Biological Processpyridoxine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pyridoxal 5'-phosphate synthase subunit PdxT
  • EC number
  • Alternative names
    • Pdx2
    • Pyridoxal 5'-phosphate synthase glutaminase subunit
      (EC:3.5.1.2
      ) . EC:3.5.1.2 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      pdxT
    • ORF names
      GX426_08155

Organism names

Accessions

  • Primary accession
    A0A7K4AJ78

Proteomes

Subcellular Location

Interaction

Subunit

In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.

Family & Domains

Sequence similarities

Belongs to the glutaminase PdxT/SNO family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    192
  • Mass (Da)
    20,602
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    8C41836DE9D8CB40F4CB08D1CE78C1EA
MPKIGVLALQGDVSEHVDALQRIGEGIDVLEVRKPGQIASCSALVLPGGESTTIVQQLNSSGLAGELEAAATTGLPILATCAGLVLISREIEGDNHVQPLGLMDIKISRNAFGPQRESFEADLDVEDMDRPYRAVFIRAPVVSEVGRDVQVLAKVGGLPVAVREKNLLGLAFHPELTDDMRFHQLFLKMLEA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAYUN010000141
EMBL· GenBank· DDBJ
NLJ23066.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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