A0A7K4AI92 · A0A7K4AI92_METSH
- ProteinPutative adenylate kinase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids167 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late maturation steps of the 30S ribosomal particles, specifically 16S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit.
Catalytic activity
- AMP + ATP = 2 ADP
- ATP + H2O = ADP + phosphate + H+
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 10 | ATP (UniProtKB | ChEBI) | |||
Binding site | 12 | ATP (UniProtKB | ChEBI) | |||
Binding site | 13 | ATP (UniProtKB | ChEBI) | |||
Binding site | 14 | ATP (UniProtKB | ChEBI) | |||
Binding site | 15 | ATP (UniProtKB | ChEBI) | |||
Binding site | 97 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Biological Process | phosphorylation | |
Biological Process | ribosomal small subunit biogenesis | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePutative adenylate kinase
- EC number
- Short namesAK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanotrichales > Methanotrichaceae > Methanothrix
Accessions
- Primary accessionA0A7K4AI92
Proteomes
Interaction
Subunit
Interacts with uS11. Not a structural component of 40S pre-ribosomes, but transiently interacts with them by binding to uS11.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 96-106 | LID | |||
Sequence similarities
Belongs to the adenylate kinase family. AK6 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length167
- Mass (Da)18,641
- Last updated2021-04-07 v1
- MD5 Checksum428DA10BADA56330C419A06DEB69CA4C
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAAYUN010000100 EMBL· GenBank· DDBJ | NLJ22672.1 EMBL· GenBank· DDBJ | Genomic DNA |