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A0A7K4AGV2 · A0A7K4AGV2_METSH

Function

function

Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site67Mg2+ (UniProtKB | ChEBI)
Binding site68Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site69Mg2+ (UniProtKB | ChEBI)
Binding site71Mg2+ (UniProtKB | ChEBI)
Binding site84Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site91Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmagnesium ion binding
Molecular Functionphosphoribosyl-AMP cyclohydrolase activity
Molecular Functionzinc ion binding
Biological ProcessL-histidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosyl-AMP cyclohydrolase
  • EC number
  • Short names
    PRA-CH

Gene names

    • Name
      hisI
    • ORF names
      GX426_03830

Organism names

Accessions

  • Primary accession
    A0A7K4AGV2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain20-93Phosphoribosyl-AMP cyclohydrolase

Sequence similarities

Belongs to the PRA-CH family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    112
  • Mass (Da)
    12,912
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    345BF087DB41C55BC503820A04BC719D
MNERLIPAIAQDWRTGEVLMLAYMNDEALAKTQETGKAHYWSRSRNKLWLKGESSGHFQLVREIRVDCDEDAILLLIEQEGGACHTGYRSCFYRTIDGRVVGEKVFDPQDVY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JAAYUN010000066
EMBL· GenBank· DDBJ
NLJ22221.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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