A0A7J8HH20 · A0A7J8HH20_MOLMO

Function

function

Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site14-19ITP (UniProtKB | ChEBI)
Binding site31Mg2+ (UniProtKB | ChEBI)
Binding site31-32ITP (UniProtKB | ChEBI)
Binding site108-111ITP (UniProtKB | ChEBI)
Binding site131ITP (UniProtKB | ChEBI)
Binding site136-137ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmetal ion binding
Molecular Functionnucleoside triphosphate diphosphatase activity
Molecular Functionnucleotide binding
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      ITPA
    • ORF names
      HJG59_006991

Organism names

Accessions

  • Primary accession
    A0A7J8HH20

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylalanine

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    167
  • Mass (Da)
    18,280
  • Last updated
    2021-04-07 v1
  • Checksum
    3B85A360D8A436D2
MAASLAGKKIVFVTGNAKKLEEVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFAFSTGDSSEPVRLFRGRTSGRIVAPRGCRDFGWDPCFQPDGYEQTYAEMPKAEKNAISHRFRALRELQEYFGGLTSGASDEHAHRGSGEG

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7J8HGK1A0A7J8HGK1_MOLMOITPA208
A0A7J8HGL5A0A7J8HGL5_MOLMOHJG59_006991134
A0A7J8HHM3A0A7J8HHM3_MOLMOHJG59_006991148

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACASF010000006
EMBL· GenBank· DDBJ
KAF6471428.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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