A0A7J8H095 · A0A7J8H095_ROUAE

Function

function

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular Functiongrowth factor activity
Molecular Functionhormone activity
Molecular Functioninsulin-like growth factor receptor binding
Molecular Functionprotein serine/threonine kinase activator activity
Biological Processglucose metabolic process
Biological Processossification
Biological Processpositive regulation of activated T cell proliferation
Biological Processpositive regulation of cell division
Biological Processpositive regulation of glycogen (starch) synthase activity
Biological Processpositive regulation of insulin receptor signaling pathway
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of peptidyl-tyrosine phosphorylation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processpositive regulation of vascular endothelial cell proliferation
Biological Processregulation of muscle cell differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Insulin-like growth factor II

Gene names

    • ORF names
      HJG63_006623

Organism names

Accessions

  • Primary accession
    A0A7J8H095

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_502954062525-196Insulin-like growth factor II
Disulfide bond33↔81
Disulfide bond45↔94
Disulfide bond80↔85

Keywords

Interaction

Subunit

Interacts with MYORG; this interaction is required for IGF2 secretion. Interacts with integrins ITGAV:ITGB3 and ITGA6:ITGB4; integrin-binding is required for IGF2 signaling.

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain30-94Insulin-like
Region174-196Disordered

Sequence similarities

Belongs to the insulin family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    196
  • Mass (Da)
    21,685
  • Last updated
    2021-04-07 v1
  • Checksum
    E3D6987E516440C6
MELPMPKSVLAALAFLALASCCFAAYRPSETLCGGELVDTLQFVCGDRGFYFRTLSPSLGLPGRPASRANRRSRGIVEECCFRSCDLALLETYCAAPAKSERDVSTSPTVLPDNFPRYPVGKFFQYDSWMQSAQRLRRGLPALLRVRRGRMLARELEAFREATRHRPLMVLSTDDPAAHDSTAHGGASPEGPNNRK

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7J8H013A0A7J8H013_ROUAEHJG63_006623186
A0A7J8H106A0A7J8H106_ROUAEHJG63_006623202

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACASE010000005
EMBL· GenBank· DDBJ
KAF6465510.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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