A0A7J8FYK1 · A0A7J8FYK1_MOLMO

Function

function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Molecular FunctionGTP binding
Molecular Functionhydrolase activity
Molecular Functionstructural constituent of cytoskeleton
Biological Processmicrotubule cytoskeleton organization
Biological Processmitotic cell cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Tubulin alpha chain

Gene names

    • ORF names
      HJG59_008202

Organism names

Accessions

  • Primary accession
    A0A7J8FYK1

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain49-246Tubulin/FtsZ GTPase
Domain248-377Tubulin/FtsZ 2-layer sandwich
Region416-435Disordered

Sequence similarities

Belongs to the tubulin family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    435
  • Mass (Da)
    48,286
  • Last updated
    2021-04-07 v1
  • Checksum
    17EDA98608AB1958
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7J8FZR9A0A7J8FZR9_MOLMOHJG59_008202451
A0A7J8G0F2A0A7J8G0F2_MOLMOHJG59_008202416
A0A7J8G0G1A0A7J8G0G1_MOLMOHJG59_008202161
A0A7J8FZ13A0A7J8FZ13_MOLMOHJG59_008202257
A0A7J8FZG6A0A7J8FZG6_MOLMOHJG59_008202268
A0A7J8FYK8A0A7J8FYK8_MOLMOHJG59_008202292
A0A7J8FYX0A0A7J8FYX0_MOLMOHJG59_008202131
A0A7J8FZ71A0A7J8FZ71_MOLMOHJG59_008202133
A0A7J8FYT6A0A7J8FYT6_MOLMOHJG59_008202231

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACASF010000010
EMBL· GenBank· DDBJ
KAF6452884.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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