A0A7J8DJV0 · A0A7J8DJV0_ROUAE
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1216 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 331 | ||||
Binding site | 332 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 361 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 363 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 378 | ||||
Binding site | 412 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nuclear speck | |
Molecular Function | calcium ion binding | |
Molecular Function | calmodulin binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | memory | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Pteropodoidea > Pteropodidae > Rousettinae > Rousettus
Accessions
- Primary accessionA0A7J8DJV0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 469-534 | Disordered | |||
Compositional bias | 480-500 | Polar residues | |||
Compositional bias | 507-521 | Acidic residues | |||
Domain | 540-656 | PI-PLC Y-box | |||
Domain | 656-786 | C2 | |||
Region | 834-891 | Disordered | |||
Compositional bias | 851-883 | Polar residues | |||
Compositional bias | 956-982 | Basic and acidic residues | |||
Region | 956-994 | Disordered | |||
Region | 1072-1095 | Disordered | |||
Region | 1172-1216 | Disordered | |||
Compositional bias | 1175-1194 | Polar residues | |||
Compositional bias | 1195-1216 | Basic and acidic residues | |||
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,216
- Mass (Da)138,624
- Last updated2021-04-07 v1
- MD5 Checksum51BD9EB9F1F455F122322EB37698D017
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7J8DK68 | A0A7J8DK68_ROUAE | HJG63_015428 | 1173 | ||
A0A7J8DJH6 | A0A7J8DJH6_ROUAE | HJG63_015428 | 582 | ||
A0A7J8DK05 | A0A7J8DK05_ROUAE | HJG63_015428 | 295 | ||
A0A7J8DJJ9 | A0A7J8DJJ9_ROUAE | HJG63_015428 | 1124 | ||
A0A7J8DJK8 | A0A7J8DJK8_ROUAE | HJG63_015428 | 530 | ||
A0A7J8DK70 | A0A7J8DK70_ROUAE | HJG63_015428 | 174 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 480-500 | Polar residues | |||
Compositional bias | 507-521 | Acidic residues | |||
Compositional bias | 851-883 | Polar residues | |||
Compositional bias | 956-982 | Basic and acidic residues | |||
Compositional bias | 1175-1194 | Polar residues | |||
Compositional bias | 1195-1216 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACASE010000012 EMBL· GenBank· DDBJ | KAF6423390.1 EMBL· GenBank· DDBJ | Genomic DNA |