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A0A7J8DJV0 · A0A7J8DJV0_ROUAE

Function

function

Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site331
Binding site332Ca2+ (UniProtKB | ChEBI)
Binding site361Ca2+ (UniProtKB | ChEBI)
Binding site363Ca2+ (UniProtKB | ChEBI)
Active site378
Binding site412Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnuclear speck
Molecular Functioncalcium ion binding
Molecular Functioncalmodulin binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processlipid catabolic process
Biological Processmemory
Biological Processphosphatidylinositol-mediated signaling
Biological Processrelease of sequestered calcium ion into cytosol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • ORF names
      HJG63_015428

Organism names

Accessions

  • Primary accession
    A0A7J8DJV0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region469-534Disordered
Compositional bias480-500Polar residues
Compositional bias507-521Acidic residues
Domain540-656PI-PLC Y-box
Domain656-786C2
Region834-891Disordered
Compositional bias851-883Polar residues
Compositional bias956-982Basic and acidic residues
Region956-994Disordered
Region1072-1095Disordered
Region1172-1216Disordered
Compositional bias1175-1194Polar residues
Compositional bias1195-1216Basic and acidic residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,216
  • Mass (Da)
    138,624
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    51BD9EB9F1F455F122322EB37698D017
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSAIVTPIILRSDPQGFFFYWTDQNKETELLDLSLVKDARCGKHARAPKDPKLRELLDVGNIGRLEHRMITVVYGADLVNISYLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQDDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLDSGVPLPSPMDLMYKILVKNKKKSHKSSEGSNKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNRSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRILPVPAIRPGYHYICLRNERNQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSEARTTPAENGVNHTTSLAPKPPSQALHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRTALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHSSAPSSLTSDPGKLNHKPPSSEELEGDHPGREFDTPL

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7J8DK68A0A7J8DK68_ROUAEHJG63_0154281173
A0A7J8DJH6A0A7J8DJH6_ROUAEHJG63_015428582
A0A7J8DK05A0A7J8DK05_ROUAEHJG63_015428295
A0A7J8DJJ9A0A7J8DJJ9_ROUAEHJG63_0154281124
A0A7J8DJK8A0A7J8DJK8_ROUAEHJG63_015428530
A0A7J8DK70A0A7J8DK70_ROUAEHJG63_015428174

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias480-500Polar residues
Compositional bias507-521Acidic residues
Compositional bias851-883Polar residues
Compositional bias956-982Basic and acidic residues
Compositional bias1175-1194Polar residues
Compositional bias1195-1216Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACASE010000012
EMBL· GenBank· DDBJ
KAF6423390.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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