A0A7J8BTB3 · A0A7J8BTB3_ROUAE
- ProteinLon protease homolog, mitochondrial
- GeneLONP1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids974 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.
Catalytic activity
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 527-534 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial matrix | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | ATP-dependent peptidase activity | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | serine-type endopeptidase activity | |
Molecular Function | single-stranded DNA binding | |
Biological Process | cellular response to oxidative stress | |
Biological Process | chaperone-mediated protein complex assembly | |
Biological Process | mitochondrion organization | |
Biological Process | oxidation-dependent protein catabolic process | |
Biological Process | protein quality control for misfolded or incompletely synthesized proteins |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLon protease homolog, mitochondrial
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yinpterochiroptera > Pteropodoidea > Pteropodidae > Rousettinae > Rousettus
Accessions
- Primary accessionA0A7J8BTB3
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for transit peptide, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transit peptide | 1-67 | Mitochondrion | |||
Chain | PRO_5029990709 | 68-974 | Lon protease homolog, mitochondrial | ||
Interaction
Subunit
Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 76-106 | Disordered | |||
Domain | 128-374 | Lon N-terminal | |||
Compositional bias | 226-259 | Basic and acidic residues | |||
Region | 226-262 | Disordered | |||
Region | 786-805 | Disordered | |||
Compositional bias | 788-802 | Basic and acidic residues | |||
Region | 880-940 | Disordered | |||
Compositional bias | 911-940 | Basic and acidic residues | |||
Sequence similarities
Belongs to the peptidase S16 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length974
- Mass (Da)108,063
- Last updated2021-04-07 v1
- MD5 Checksum1588A8B15E8A5E6F0D21F9C377178BFD
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7J8BSB2 | A0A7J8BSB2_ROUAE | LONP1 | 829 | ||
A0A7J8BSB3 | A0A7J8BSB3_ROUAE | LONP1 | 973 | ||
A0A7J8BS03 | A0A7J8BS03_ROUAE | LONP1 | 937 | ||
A0A7J8BS26 | A0A7J8BS26_ROUAE | LONP1 | 895 | ||
A0A7J8BT50 | A0A7J8BT50_ROUAE | LONP1 | 963 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 226-259 | Basic and acidic residues | |||
Compositional bias | 788-802 | Basic and acidic residues | |||
Compositional bias | 911-940 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACASE010000016 EMBL· GenBank· DDBJ | KAF6401635.1 EMBL· GenBank· DDBJ | Genomic DNA |