A0A7J8BLU6 · A0A7J8BLU6_MOLMO
- ProteinTyrosine-protein kinase receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids864 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for site, binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 516 | Interaction with SHC1 | |||
Binding site | 544-552 | ATP (UniProtKB | ChEBI) | |||
Binding site | 572 | ATP (UniProtKB | ChEBI) | |||
Active site | 679 | Proton acceptor | |||
Site | 859 | Interaction with PLCG1 | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | neurotrophin binding | |
Molecular Function | neurotrophin receptor activity | |
Molecular Function | transmembrane receptor protein tyrosine kinase activity | |
Biological Process | cell differentiation | |
Biological Process | cell surface receptor protein tyrosine kinase signaling pathway | |
Biological Process | cellular response to nerve growth factor stimulus | |
Biological Process | nervous system development | |
Biological Process | positive regulation of kinase activity | |
Biological Process | positive regulation of neuron projection development | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTyrosine-protein kinase receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Molossidae > Molossus
Accessions
- Primary accessionA0A7J8BLU6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 430-453 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-31 | ||||
Chain | PRO_5029882235 | 32-864 | Tyrosine-protein kinase receptor | ||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 210-300 | Ig-like | |||
Domain | 538-853 | Protein kinase | |||
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length864
- Mass (Da)96,956
- Last updated2021-04-07 v1
- MD5 Checksum7E88B9084589BFBEC0EC73462CA50EF9
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7J8BM98 | A0A7J8BM98_MOLMO | HJG59_013353 | 825 | ||
A0A7J8BLL1 | A0A7J8BLL1_MOLMO | HJG59_013353 | 850 | ||
A0A7J8BLQ8 | A0A7J8BLQ8_MOLMO | HJG59_013353 | 817 | ||
A0A7J8BLS7 | A0A7J8BLS7_MOLMO | HJG59_013353 | 335 | ||
A0A7J8BKN3 | A0A7J8BKN3_MOLMO | HJG59_013353 | 839 | ||
A0A7J8BL01 | A0A7J8BL01_MOLMO | HJG59_013353 | 259 | ||
A0A7J8BKK9 | A0A7J8BKK9_MOLMO | HJG59_013353 | 140 | ||
A0A7J8BKZ9 | A0A7J8BKZ9_MOLMO | HJG59_013353 | 831 | ||
A0A7J8BKZ5 | A0A7J8BKZ5_MOLMO | HJG59_013353 | 612 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACASF010000024 EMBL· GenBank· DDBJ | KAF6399395.1 EMBL· GenBank· DDBJ | Genomic DNA |