A0A7J8B0Z3 · A0A7J8B0Z3_PIPKU
- ProteinVascular endothelial growth factor receptor 2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1350 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 835-842 | ATP (UniProtKB | ChEBI) | |||
Binding site | 862 | ATP (UniProtKB | ChEBI) | |||
Active site | 1022 | Proton acceptor | |||
Binding site | 1026 | ATP (UniProtKB | ChEBI) | |||
Binding site | 1027 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 1040 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | growth factor binding | |
Molecular Function | metal ion binding | |
Molecular Function | vascular endothelial growth factor receptor activity | |
Biological Process | angiogenesis | |
Biological Process | cell migration | |
Biological Process | endothelial cell differentiation | |
Biological Process | positive regulation of angiogenesis | |
Biological Process | positive regulation of cell migration | |
Biological Process | positive regulation of kinase activity | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of MAPK cascade | |
Biological Process | vascular endothelial growth factor receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameVascular endothelial growth factor receptor 2
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Pipistrellus
Accessions
- Primary accessionA0A7J8B0Z3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-19 | ||||
Chain | PRO_5029543645 | 20-1350 | Vascular endothelial growth factor receptor 2 | ||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 224-321 | Ig-like | |||
Domain | 329-415 | Ig-like | |||
Domain | 422-545 | Ig-like | |||
Domain | 552-654 | Ig-like | |||
Domain | 661-733 | Ig-like | |||
Domain | 828-1156 | Protein kinase | |||
Region | 1274-1316 | Disordered | |||
Compositional bias | 1280-1309 | Polar residues | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,350
- Mass (Da)151,334
- Last updated2021-04-07 v1
- MD5 Checksum56C4AD067C9560E58DFAFD11812281CF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1280-1309 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACAGB010000001 EMBL· GenBank· DDBJ | KAF6392302.1 EMBL· GenBank· DDBJ | Genomic DNA |