A0A7J7ZHN2 · A0A7J7ZHN2_PIPKU
- ProteinFibroblast growth factor receptor
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids729 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 391-397 | ATP (UniProtKB | ChEBI) | |||
Binding site | 421 | ATP (UniProtKB | ChEBI) | |||
Binding site | 469-471 | ATP (UniProtKB | ChEBI) | |||
Binding site | 475 | ATP (UniProtKB | ChEBI) | |||
Active site | 530 | Proton acceptor | |||
Binding site | 534 | ATP (UniProtKB | ChEBI) | |||
Binding site | 548 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic vesicle | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | ATP binding | |
Molecular Function | fibroblast growth factor binding | |
Molecular Function | fibroblast growth factor receptor activity | |
Biological Process | animal organ development | |
Biological Process | positive regulation of cell differentiation | |
Biological Process | positive regulation of cell population proliferation | |
Biological Process | positive regulation of kinase activity | |
Biological Process | protein phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFibroblast growth factor receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Pipistrellus
Accessions
- Primary accessionA0A7J7ZHN2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 286-306 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_5029530049 | 22-729 | Fibroblast growth factor receptor | ||
Disulfide bond | 87↔139 | ||||
Disulfide bond | 186↔250 | ||||
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 24-65 | Disordered | |||
Compositional bias | 33-48 | Acidic residues | |||
Domain | 67-155 | Ig-like | |||
Domain | 164-266 | Ig-like | |||
Domain | 385-674 | Protein kinase | |||
Compositional bias | 685-701 | Polar residues | |||
Region | 685-729 | Disordered | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length729
- Mass (Da)81,672
- Last updated2021-04-07 v1
- MD5 Checksum2BCC3F445AAA6EAF497466EA42ECAE14
Computationally mapped potential isoform sequences
There are 7 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7J7ZHB9 | A0A7J7ZHB9_PIPKU | mPipKuh1_005065 | 820 | ||
A0A7J7ZHC0 | A0A7J7ZHC0_PIPKU | mPipKuh1_005065 | 500 | ||
A0A7J7ZIA1 | A0A7J7ZIA1_PIPKU | mPipKuh1_005065 | 818 | ||
A0A7J7ZI01 | A0A7J7ZI01_PIPKU | mPipKuh1_005065 | 604 | ||
A0A7J7ZHW8 | A0A7J7ZHW8_PIPKU | mPipKuh1_005065 | 731 | ||
A0A7J7ZHS4 | A0A7J7ZHS4_PIPKU | mPipKuh1_005065 | 731 | ||
A0A7J7ZIY2 | A0A7J7ZIY2_PIPKU | mPipKuh1_005065 | 228 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 33-48 | Acidic residues | |||
Compositional bias | 685-701 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACAGB010000003 EMBL· GenBank· DDBJ | KAF6373654.1 EMBL· GenBank· DDBJ | Genomic DNA |