A0A7J7UUD3 · A0A7J7UUD3_PIPKU

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + (9Z)-octadecenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 2-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + hexadecanoate + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + H2O = 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z,15Z)-octadecatrienoate + 1-octadecanoyl-sn-glycero-3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + glycerol = 1-(9Z,12Z,15Z-octadecatrienoyl)-glycerol + 1-octadecanoyl-sn-glycero-3-phosphocholine
    This reaction proceeds in the forward direction.
  • 2-(prostaglandin E2)-sn-glycero-3-phosphocholine + H2O = prostaglandin E2 + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine + H2O = sn-glycero-3-phosphoethanolamine + prostaglandin E2 + H+
    This reaction proceeds in the forward direction.
  • 2-[(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 2-[(15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • 2-[(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-sn-glycero-3-phosphocholine + H2O = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + sn-glycerol 3-phosphocholine + H+
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.4 (UniProtKB | ENZYME | Rhea)
  • a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H+
    This reaction proceeds in the forward direction.
    EC:3.1.1.5 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism; arachidonate metabolism.
Lipid metabolism; leukotriene B4 biosynthesis.
Lipid metabolism; prostaglandin biosynthesis.
Membrane lipid metabolism; glycerophospholipid metabolism.

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular Componentnuclear envelope
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functioncalcium-dependent phospholipid binding
Biological Processglycerol metabolic process
Biological Processglycerophospholipid catabolic process
Biological Processleukotriene biosynthetic process
Biological Processprostaglandin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2
  • EC number

Gene names

    • ORF names
      mPipKuh1_013621

Organism names

  • Taxonomic identifier
  • Strain
    • MPipKuh1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Pipistrellus

Accessions

  • Primary accession
    A0A7J7UUD3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Interacts with KAT5.

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain6-122C2
Domain138-740PLA2c
Compositional bias428-451Basic and acidic residues
Region428-457Disordered

Domain

The N-terminal C2 domain associates with lipid membranes upon calcium binding.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    749
  • Mass (Da)
    85,555
  • Last updated
    2021-04-07 v1
  • Checksum
    5A35D0E890CD8518
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDLLDTPDPYVELFISSTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPISSMKVGEKKEVPFIFNQVTEMILEMSLEVCSSPDLRFSMALCDQEKAFRYQRKENVKENMKKLLGLENSESLCSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKRSGQPVTFADIFGMLIGETLIHNRMNMTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFTPYEIGMAKYGTFMTPDLFGSKFFMGKVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSSSHNKGSTMEEELENITAKHIVSNDSSDSDDESQGPKGTEAEDAEEEYQNDYQASWVQRMIMALMSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPFRDFDTQESWEEDELDAAVTDPDEFEQIYEPLDVKSKKIHIVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPNVFDREGLKECYVFKPKNSDMDKDCPTVIHFVLANINFRKYKAPGVPRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKSAILESIEYRRQNPSRCSVSLSNVEARKFFNKEFLSKPPA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7J7UU10A0A7J7UU10_PIPKUmPipKuh1_013621741

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias428-451Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACAGB010000018
EMBL· GenBank· DDBJ
KAF6316394.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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