A0A7J7S614 · A0A7J7S614_PIPKU
- ProteinMyotubularin
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids601 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
Catalytic activity
- 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-phosphate) + H2O = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 312-313 | substrate | |||
Active site | 374 | Phosphocysteine intermediate | |||
Binding site | 374-380 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | filopodium | |
Cellular Component | late endosome | |
Cellular Component | plasma membrane | |
Cellular Component | ruffle | |
Cellular Component | sarcomere | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Molecular Function | phosphoprotein phosphatase activity | |
Biological Process | mitochondrion distribution | |
Biological Process | muscle cell cellular homeostasis | |
Biological Process | negative regulation of autophagosome assembly | |
Biological Process | phosphatidylinositol dephosphorylation |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMyotubularin
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Pipistrellus
Accessions
- Primary accessionA0A7J7S614
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Heterodimer with MTMR12. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle. Interacts with SPEG.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-34 | Disordered | |||
Compositional bias | 14-31 | Basic and acidic residues | |||
Domain | 162-537 | Myotubularin phosphatase | |||
Domain | 343-405 | Tyrosine specific protein phosphatases | |||
Region | 577-601 | Disordered | |||
Sequence similarities
Family and domain databases
Sequence
- Sequence statusComplete
- Length601
- Mass (Da)69,766
- Last updated2021-04-07 v1
- MD5 Checksum61BB32540BCF6D42D22DFA80F473B0BD
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A7J7S5N4 | A0A7J7S5N4_PIPKU | mPipKuh1_011903 | 602 | ||
A0A7J7S5K5 | A0A7J7S5K5_PIPKU | mPipKuh1_011903 | 423 | ||
A0A7J7S598 | A0A7J7S598_PIPKU | mPipKuh1_011903 | 571 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 14-31 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACAGB010000049 EMBL· GenBank· DDBJ | KAF6283615.1 EMBL· GenBank· DDBJ | Genomic DNA |