A0A7J7S614 · A0A7J7S614_PIPKU

Function

function

Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site312-313substrate
Active site374Phosphocysteine intermediate
Binding site374-380substrate

GO annotations

AspectTerm
Cellular Componentfilopodium
Cellular Componentlate endosome
Cellular Componentplasma membrane
Cellular Componentruffle
Cellular Componentsarcomere
Molecular Functionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Molecular Functionphosphatidylinositol-3-phosphate phosphatase activity
Molecular Functionphosphoprotein phosphatase activity
Biological Processmitochondrion distribution
Biological Processmuscle cell cellular homeostasis
Biological Processnegative regulation of autophagosome assembly
Biological Processphosphatidylinositol dephosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Myotubularin
  • EC number
  • Alternative names
    • Phosphatidylinositol-3,5-bisphosphate 3-phosphatase
    • Phosphatidylinositol-3-phosphate phosphatase

Gene names

    • ORF names
      mPipKuh1_011903

Organism names

  • Taxonomic identifier
  • Strain
    • MPipKuh1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Pipistrellus

Accessions

  • Primary accession
    A0A7J7S614

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell projection, filopodium
Cell projection, ruffle
Cytoplasm, myofibril, sarcomere
Late endosome

Keywords

Interaction

Subunit

Heterodimer with MTMR12. Interacts with KMT2A/MLL1 (via SET domain). Interacts with DES in skeletal muscle but not in cardiac muscle. Interacts with SPEG.

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-34Disordered
Compositional bias14-31Basic and acidic residues
Domain162-537Myotubularin phosphatase
Domain343-405Tyrosine specific protein phosphatases
Region577-601Disordered

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    601
  • Mass (Da)
    69,766
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    61BB32540BCF6D42D22DFA80F473B0BD
MASASTSKYNSHSLENESIKRTSRDGVNRDLSEAVPRLPGETRITDKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSALLDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPIFAFLNEEKFNVDGWMVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPPLLVVPFRATDEDLKRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNRQISKLTIYDARPSVNAVANKATGGGYESDDAYHNTELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLILTGAIQVADKVSSGRSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHADADRSPIFLQFIDCVWQMSKQFPTAFEFNERFLMTILDHLYSCRFGTFLYNCESARERQKVTERTASLWSLINSNKDTFKNPFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPSTSPSSPSQMLPHVQTHF

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7J7S5N4A0A7J7S5N4_PIPKUmPipKuh1_011903602
A0A7J7S5K5A0A7J7S5K5_PIPKUmPipKuh1_011903423
A0A7J7S598A0A7J7S598_PIPKUmPipKuh1_011903571

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias14-31Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACAGB010000049
EMBL· GenBank· DDBJ
KAF6283615.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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