A0A7J7RA62 · A0A7J7RA62_PIPKU

Function

function

A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site144[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site162[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site171[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site206[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Function4 iron, 4 sulfur cluster binding
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA helicase activity
Molecular FunctionDNA polymerase binding
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Functionmetal ion binding
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA replication
Biological Processnegative regulation of DNA recombination
Biological Processnegative regulation of t-circle formation
Biological Processregulation of double-strand break repair via homologous recombination
Biological Processtelomeric loop disassembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Regulator of telomere elongation helicase 1
  • EC number

Gene names

    • Name
      RTEL1
    • ORF names
      mPipKuh1_015252

Organism names

  • Taxonomic identifier
  • Strain
    • MPipKuh1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Chiroptera > Yangochiroptera > Vespertilionidae > Pipistrellus

Accessions

  • Primary accession
    A0A7J7RA62

Proteomes

Subcellular Location

Nucleus
Note: Colocalizes with PCNA within the replication foci in S-phase cells.

Keywords

  • Cellular component

Interaction

Subunit

Interacts with TERF1. Interacts (via PIP-box) with PCNA; the interaction is direct and essential for suppressing telomere fragility. Interacts with MMS19; the interaction mediates the association of RTEL1 with the cytosolic iron-sulfur protein assembly (CIA) complex.

Family & Domains

Features

Showing features for domain, motif, region.

Type
IDPosition(s)Description
Domain7-295Helicase ATP-binding
Motif150-166Nuclear localization signal
Region843-863Disordered
Region974-1054Disordered
Region1136-1191Disordered

Sequence similarities

Belongs to the helicase family. RAD3/XPD subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,191
  • Mass (Da)
    130,952
  • Last updated
    2021-04-07 v1
  • MD5 Checksum
    BFD3C7F81CBA5EE0F0BBF608895C0455
MPKIILSGVTVDFPFQPYKCQEEYMTKVLECLQKKVNGVLESPTGTGKTLCLLCSTLAWREHLRDAISARKIAERTQGDLFLSRPLSSWGNAASEEDATACYADIPKIIYASRTHSQLTQVIGELRNTSYRPRVCVLGSREQLCIHPEVKKQESNHMQIHLCRKKVASRSCHFYNNIEEKSLEHDLATPILDIEDLVKSGNRHKLCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHGIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDVASGLDVIDQVLEEQSRAAQQGELRLEFSADANSGLNMELEDIAKLKMILLRLEGAIDAVELPGGDGGVTKPGSYIFELFAEAQITLQTKGCILESLDQIIQHLAGRAGLFTNTAGLQKLADIIQMVFSADPAEGSSPVGPGASQSYKVHIHPDTSHRGTAHRPDAWSSTASRRRGKVLSYWCFSPGCSMRELVGQGVRTLLLTSGTLAPVASFALEMQIPFPVCLENPHVIDKHQIWVGIVPKGPDGAQLSSAFDRRFSDECLSSLGKTLVNITRVVPHGLLVFFPSYPVLEKSLEFWRARDWARKLEALKPLFVEPRSKDSFSEVMGAYYTSVVSPGSRGAAFLAVCRGKASEGLDFADMNGRGVVVTGLPYPPRKDPRVILKMQFLDEMKGRSGASGQFLSGQDWYRQQASRAVNQAIGRVIRHRHDYGAVFLCDHRFTSADARAQLPSWVRPHVQVYDHFGHVIRDVAQFFRAAQRTMPAPLAAPPSPARGEGAVPVAVSLRALSTKKAKSLDLHVPSLRQGPPGLPASGDGGDAAGSLCVEYEQESVHTQRRPVGLLAALEHSEQLARRPGEEEAQCHSGPALPGEKRTVAEQRAARKKIRLVSCQEGLAAGAQADRAKLFMVAVKQALSRASFAAFTRALQEYKGSDDFQALADHLSPLFAQDPEKHSLLQGFYQFVRPHHKQRFEELCLQLTGRGCSHPPEHSLPRGQWAQPALDPGGRREPVPKVTMSQSAARQLDTGGHLNCGQPHLASRPPPEGDAGLCAQEGRGAPQAQKPSPPVVSAYLADARRALGAGGCRQLLAALTTYKRDDDFDKVVAVVAALTTSRPEDLPLLQRFSMFVRPHHKLRFWQMWADLTGRPTPDTGTVPPGLQEGSSEAFPSLTPRALRPGPSDQERPGRTQSKISSFLRPRLDPQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACAGB010000087
EMBL· GenBank· DDBJ
KAF6272963.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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