A0A7J7FMS8 · A0A7J7FMS8_DICBM
- Proteinacetyl-CoA carboxylase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids2342 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Catalytic activity
- acetyl-CoA + ATP + hydrogencarbonate = ADP + H+ + malonyl-CoA + phosphateThis reaction proceeds in the forward direction.
Cofactor
Pathway
Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | acetyl-CoA carboxylase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | malonyl-CoA biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameacetyl-CoA carboxylase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7FMS8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 79-597 | Biotin carboxylation | ||||
Sequence: VIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADQYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLRKHGIAFLGPPSEAMWALGDKIASTIVAQTLQIPTLPWSGSGLTVEWAEDDLQQGKRISVPEDVYDQGCVKDVDEGLEAAEKIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPVFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIIEEAPTTIATPAVFEFMEQCAVRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEARFNSDANISGVMLCSILLFLSGFQGFKPSSGTVQELNFRSSRNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDHLIA | ||||||
Domain | 234-433 | ATP-grasp | ||||
Sequence: DDLQQGKRISVPEDVYDQGCVKDVDEGLEAAEKIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPVFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIIEEAPTTIATPAVFEFMEQCAVRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADIAMGVPLHRLKDIRLL | ||||||
Domain | 724-798 | Lipoyl-binding | ||||
Sequence: FEKENDPTVLRSPSAGKLMQYTVEDGGHVEAGSSYAEMEVMKMIMTLNAQESGRVRYVKRPGAVLEAGCVVARLE | ||||||
Domain | 1565-1895 | CoA carboxyltransferase N-terminal | ||||
Sequence: PYVTKDLLQAKRFQAQSLGTTYALFKLWGSPDKYPKDILTYSELVLDPQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVISNDITFRIGSFGLGEDLLYLRASELARAEGIPKIYLAANSGARIGLAEEIKHMFQVAWVDPEDPHKGFKYLYLTPQDYTRISSLNSVHCKHIEEDGESRYVITDIIGKDDGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRALGIGAYLVRLGQRVIQVENSHIILTGAGALNKDLANPAASKQVLGREVYTSNNQLGGVQIMHYNGISHSTVPDDFEGVYTILEWLSYMPKDNRSPVPIIT | ||||||
Domain | 1899-2229 | CoA carboxyltransferase C-terminal | ||||
Sequence: PIDREIEFLPSRAPYNPRWMLAGRPHPRILAEWILRPGHFQGNHGALGPDRGDGTSKPTGVPPSARLTCAPPCRLGGIPVGVIAVETRMVEVVVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAIKDFNQEKLPLMIFANWRGFSGGMKDMYDQVLKFGAYIVDGLRQYKQPVLIYIPPYAELRGGSWVVLDSTINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLIKAMRRIDPAYRKLVEQLGVSELSDEDRKDLEGRLKAREDLLLPIYHQVAAQFADLHDTPGRMLEKGVISDVLEWKSARTFLYWRLRRLLLEDQVKQEILR | ||||||
Region | 1940-1960 | Disordered | ||||
Sequence: GNHGALGPDRGDGTSKPTGVP |
Family and domain databases
Sequence
- Sequence statusComplete
- Length2,342
- Mass (Da)263,742
- Last updated2021-04-07 v1
- Checksum58E8DDA185BA4749
Keywords
- Technical term