A0A7J7FKG4 · A0A7J7FKG4_DICBM

Function

function

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site90Ca2+ 1 (UniProtKB | ChEBI)
Binding site91Ca2+ 1 (UniProtKB | ChEBI)
Binding site91Ca2+ 2 (UniProtKB | ChEBI)
Binding site96Ca2+ 1 (UniProtKB | ChEBI)
Binding site126Ca2+ 1 (UniProtKB | ChEBI)
Binding site127Ca2+ 2 (UniProtKB | ChEBI)
Binding site127Ca2+ 1 (UniProtKB | ChEBI)
Binding site130Ca2+ 2 (UniProtKB | ChEBI)
Binding site132Ca2+ 2 (UniProtKB | ChEBI)
Binding site141Zn2+ (UniProtKB | ChEBI)
Binding site148Zn2+ (UniProtKB | ChEBI)
Binding site183Zn2+ (UniProtKB | ChEBI)
Site198-199Cleavage; by autolysis
Site244Involved in cholesterol transfer
Site268Involved in auto-cleavage
Site271Essential for auto-cleavage

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular space
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionpatched binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processcell fate specification
Biological Processcell-cell signaling
Biological Processintein-mediated protein splicing
Biological Processprotein autoprocessing
Biological Processregulation of gene expression
Biological Processsmoothened signaling pathway
Biological Processsystem development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • ORF names
      HPG69_015161

Organism names

Accessions

  • Primary accession
    A0A7J7FKG4

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
Membrane
; Lipid-anchor

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_502956864823-396Hedgehog protein

Keywords

Interaction

Subunit

Multimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain197-304Hint
Domain305-349Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    396
  • Mass (Da)
    43,534
  • Last updated
    2021-04-07 v1
  • Checksum
    DCF5F78E61838A71
MALPASLVPLCCLALLVLPAQSCGPGRGPVGRRRYVRKQLVPLLYKQFVPSVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDEENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLRSGERKGLRELHRGDWVLAADAAGRVVPTPVLLFLDRDLQRRASFVAVETERPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRFLYRLAEELLG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010000370
EMBL· GenBank· DDBJ
KAF5928555.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp