A0A7J7FER0 · A0A7J7FER0_DICBM
- Proteinformyltetrahydrofolate dehydrogenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids969 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- (6R)-10-formyltetrahydrofolate + H2O + NADP+ = (6S)-5,6,7,8-tetrahydrofolate + CO2 + H+ + NADPHThis reaction proceeds in the forward direction.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 131-133 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | ||||
Sequence: QFI | ||||||
Active site | 149 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 185 | (6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Site | 185 | Essential for catalytic activity | ||||
Sequence: D | ||||||
Binding site | 613-615 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: IPW | ||||||
Binding site | 639-642 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: KPAQ | ||||||
Binding site | 672-677 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GGIAGQ | ||||||
Binding site | 692-693 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: GS | ||||||
Active site | 715 | |||||
Sequence: E | ||||||
Active site | 715 | Proton acceptor | ||||
Sequence: E | ||||||
Active site | 749 | Proton donor | ||||
Sequence: C | ||||||
Binding site | 799 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 846-848 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: ESF |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | aldehyde dehydrogenase (NAD+) activity | |
Molecular Function | formyltetrahydrofolate dehydrogenase activity | |
Biological Process | 10-formyltetrahydrofolate catabolic process | |
Biological Process | biosynthetic process | |
Biological Process | one-carbon metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameformyltetrahydrofolate dehydrogenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7FER0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 360-437 | Carrier | ||||
Sequence: AEELKVAETIKVIWAGILSNIPVIENSTDFFKSGARSMDVVRLVEEIRQKCGGLQLQNEDVYMATKFEDFIQKVVRKL |
Sequence similarities
Belongs to the aldehyde dehydrogenase family.
In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.
In the N-terminal section; belongs to the GART family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length969
- Mass (Da)107,352
- Last updated2021-04-07 v1
- Checksum296E556B47F61D16
Keywords
- Technical term