A0A7J7FCI2 · A0A7J7FCI2_DICBM
- Proteinadenylate cyclase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1135 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.
Catalytic activity
- ATP = 3',5'-cyclic AMP + diphosphate
Cofactor
Protein has several cofactor binding sites:
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 278 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 278 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 278-283 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIVGFT | ||||||
Binding site | 279 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: I | ||||||
Binding site | 320-322 | ATP (UniProtKB | ChEBI) | ||||
Sequence: LGD | ||||||
Binding site | 322 | Mg2+ 2 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 322 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | ||||
Sequence: D | ||||||
Binding site | 366 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 983 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 1063-1065 | ATP (UniProtKB | ChEBI) | ||||
Sequence: DIW | ||||||
Binding site | 1070-1074 | ATP (UniProtKB | ChEBI) | ||||
Sequence: NVASR | ||||||
Binding site | 1110 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | adenylate cyclase activity | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | |
Biological Process | cAMP biosynthetic process | |
Biological Process | intracellular signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameadenylate cyclase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7FCI2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 29-49 | Helical | ||||
Sequence: LLLLLLAIVLCALLALLAVAW | ||||||
Transmembrane | 61-80 | Helical | ||||
Sequence: FLTTVLCALGGFSLLLGLAS | ||||||
Transmembrane | 92-110 | Helical | ||||
Sequence: LSGLVWAALLALGYGFLFT | ||||||
Transmembrane | 116-134 | Helical | ||||
Sequence: AWDQVSFFLFVIFTVYAML | ||||||
Transmembrane | 141-161 | Helical | ||||
Sequence: AAAAGLASSLSHLLVLGLYLG | ||||||
Transmembrane | 173-190 | Helical | ||||
Sequence: QLAANAVLFLCGNVAGAY | ||||||
Transmembrane | 623-642 | Helical | ||||
Sequence: YYAACTFLVFLSNFIIQMLV | ||||||
Transmembrane | 648-668 | Helical | ||||
Sequence: ALAITCSIAFLLFLLLLFVCF | ||||||
Transmembrane | 701-722 | Helical | ||||
Sequence: VALGTATILLVFAMAIASLFFL | ||||||
Transmembrane | 778-795 | Helical | ||||
Sequence: YSMHCCVLGFLSCSLFLH | ||||||
Transmembrane | 802-823 | Helical | ||||
Sequence: LLLLLLWLAASCSLFLHSHAWL | ||||||
Transmembrane | 848-865 | Helical | ||||
Sequence: LMGAISFFIFFFTLLVLA |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 273-400 | Guanylate cyclase | ||||
Sequence: SVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHME | ||||||
Region | 514-533 | Disordered | ||||
Sequence: MSQAEEEDEKGTAGGLLSSL | ||||||
Domain | 931-1076 | Guanylate cyclase | ||||
Sequence: CVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRME |
Sequence similarities
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,135
- Mass (Da)125,135
- Last updated2021-04-07 v1
- Checksum076E7FEC84E86D37
Keywords
- Technical term