A0A7J7FCI2 · A0A7J7FCI2_DICBM

Function

function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site278Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site278Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site278-283ATP (UniProtKB | ChEBI)
Binding site279Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site320-322ATP (UniProtKB | ChEBI)
Binding site322Mg2+ 2 (UniProtKB | ChEBI); catalytic
Binding site322Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site366ATP (UniProtKB | ChEBI)
Binding site983ATP (UniProtKB | ChEBI)
Binding site1063-1065ATP (UniProtKB | ChEBI)
Binding site1070-1074ATP (UniProtKB | ChEBI)
Binding site1110ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionadenylate cyclase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Biological ProcesscAMP biosynthetic process
Biological Processintracellular signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    adenylate cyclase
  • EC number

Gene names

    • ORF names
      HPG69_002215

Organism names

Accessions

  • Primary accession
    A0A7J7FCI2

Proteomes

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane29-49Helical
Transmembrane61-80Helical
Transmembrane92-110Helical
Transmembrane116-134Helical
Transmembrane141-161Helical
Transmembrane173-190Helical
Transmembrane623-642Helical
Transmembrane648-668Helical
Transmembrane701-722Helical
Transmembrane778-795Helical
Transmembrane802-823Helical
Transmembrane848-865Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain273-400Guanylate cyclase
Region514-533Disordered
Domain931-1076Guanylate cyclase

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,135
  • Mass (Da)
    125,135
  • Last updated
    2021-04-07 v1
  • Checksum
    076E7FEC84E86D37
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLAIVLCALLALLAVAWASGRELASDPGFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWAALLALGYGFLFTGGVVSAWDQVSFFLFVIFTVYAMLPLGMRDAAAAGLASSLSHLLVLGLYLGPQPHSRPALLPQLAANAVLFLCGNVAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAAMEHRDPYLRELGEPTYLVIDPRVKAQPGPRVLAHPTLPQPTGLLSAMPETEFLGPGVCVKGERKQAFKGCGENGEGSVILTLSPHMSQAEEEDEKGTAGGLLSSLEGPKMRPSLLMTRYLESWGAAKPFAHLSHVESPVSTSTPLPEKALASFSPQWSLDRQWKQSKDFNPLTLYFREKEMEKEYRLSALPAFKYYAACTFLVFLSNFIIQMLVTNRPPALAITCSIAFLLFLLLLFVCFSEHLTKCVLKGPKMLHWLPTLSGLVSTRPGLRVALGTATILLVFAMAIASLFFLPAAPNCPFRLPNVSSTAFNLSWELPGSLPLISVPIGPGPWGVPLPHLLTTLLAPQYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSDCLIARLCLGSSDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGIIKVKGKGQLCTYFLNTDLIRTGPPSAALG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010000812
EMBL· GenBank· DDBJ
KAF5925765.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp