A0A7J7FC18 · A0A7J7FC18_DICBM

Function

function

Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Pathway

Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site198-207FAD (UniProtKB | ChEBI)
Binding site207substrate
Binding site231-233FAD (UniProtKB | ChEBI)
Binding site255-256substrate
Binding site310substrate
Binding site317-320substrate
Active site319Proton acceptor
Binding site345FAD (UniProtKB | ChEBI)
Binding site356FAD (UniProtKB | ChEBI)
Binding site413-417FAD (UniProtKB | ChEBI)
Binding site440-441substrate
Binding site442-444FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Function3-methylbutanoyl-CoA dehydrogenase activity
Molecular Functionflavin adenine dinucleotide binding
Biological ProcessL-leucine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Isovaleryl-CoA dehydrogenase, mitochondrial
  • EC number
  • Alternative names
    • Butyryl-CoA dehydrogenase

Gene names

    • ORF names
      HPG69_002007

Organism names

Accessions

  • Primary accession
    A0A7J7FC18

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain46-79Acyl-CoA dehydrogenase/oxidase N-terminal
Region75-94Disordered
Domain106-193Acyl-CoA dehydrogenase/oxidase N-terminal
Domain197-294Acyl-CoA oxidase/dehydrogenase middle
Domain307-453Acyl-CoA dehydrogenase/oxidase C-terminal

Sequence similarities

Belongs to the acyl-CoA dehydrogenase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    49,700
  • Last updated
    2021-04-07 v1
  • Checksum
    81D8C51E55CD2511
MATVARLLGRRVVSWRLRPPLPPLAGVVSQRAHSLLPVDDAINGLSEEQKQLRQTVAKFLQDHLAPHAQEIDHSNEFKNLRVSHEAHTGGTGGQSGSWAGSCAAAAWKGSHSLLEFWKQLGKLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGTHSNLCLNQIVRNGNEAQKEKYLPKLISGEYIGALAMSESNAGSDVVSMKLKAEKKGDHYILNGNKFWITNGPDADILIVYAKTDLAAVPASRGITAFIVEKDMPGFSTSKKLDKLGMRGSNTCELIFEDCKVPATNILGHPSKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHMREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTSKDCAAVILYSAECATQVALDGIQCFGGNGXXXDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010000812
EMBL· GenBank· DDBJ
KAF5925560.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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