A0A7J7F7B0 · A0A7J7F7B0_DICBM
- ProteinLysyl oxidase homolog
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids813 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).
Catalytic activity
- L-lysyl-[protein] + O2 + H2O = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | basement membrane | |
Cellular Component | chromosome | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | extracellular space | |
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | copper ion binding | |
Molecular Function | protein-lysine 6-oxidase activity | |
Biological Process | chromatin organization | |
Biological Process | collagen fibril organization | |
Biological Process | peptidyl-lysine oxidation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysyl oxidase homolog
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7F7B0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-25 | ||||
Chain | PRO_5029798628 | 26-813 | Lysyl oxidase homolog | ||
Disulfide bond | 83↔147 | ||||
Disulfide bond | 127↔137 | ||||
Disulfide bond | 240↔250 | ||||
Disulfide bond | 370↔380 | ||||
Disulfide bond | 486↔496 | ||||
Post-translational modification
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Keywords
- PTM
Interaction
Subunit
Component of some chromatin repressor complex. Interacts with SNAI1. Interacts with TAF10. Interacts with HSPA5. Interacts with EFEMP2.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length813
- Mass (Da)90,656
- Last updated2021-04-07 v1
- ChecksumDAE24C3A86A163CE
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACDTQ010001259 EMBL· GenBank· DDBJ | KAF5923556.1 EMBL· GenBank· DDBJ | Genomic DNA |