A0A7J7F5B9 · A0A7J7F5B9_DICBM
- ProteinAldo-keto reductase family 1 member A1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids325 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
Catalytic activity
- 3-deoxyfructose + NADP+ = 3-deoxyglucosone + H+ + NADPH
- H+ + NADPH + S-nitroso-CoA = NADP+ + sulfinamide-CoAThis reaction proceeds in the forward direction.
- H+ + NADPH + S-nitrosoglutathione = NADP+ + S-(hydroxysulfenamide)glutathione
- hydroxyacetone + NADP+ = H+ + methylglyoxal + NADPH
Features
Showing features for active site, site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 50 | Proton donor | ||||
Sequence: Y | ||||||
Site | 80 | Lowers pKa of active site Tyr | ||||
Sequence: K | ||||||
Binding site | 113 | substrate | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | cytosol | |
Molecular Function | aldose reductase (NADPH) activity | |
Molecular Function | allyl-alcohol dehydrogenase activity | |
Molecular Function | glucuronolactone reductase activity | |
Molecular Function | L-glucuronate reductase activity | |
Biological Process | aldehyde catabolic process |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAldo-keto reductase family 1 member A1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7F5B9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 17-293 | NADP-dependent oxidoreductase | ||||
Sequence: IGLGTWKSEPGQVKAAIKYALSVGYRHIDCAAIYGNETEIGEALKENVGPGKAVPREELFVTSKLWNTKHHPEDVAPALRKTLADLQLEYLDLYLMHWPFAFEQGDNPFPKNADGTVRYDSTHYKETWKAMEALVAKGLVRALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPAEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICVPKSVTPSRILQNIQVFDFTFSPEEMKRLDALN |
Sequence similarities
Belongs to the aldo/keto reductase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length325
- Mass (Da)36,546
- Last updated2021-04-07 v1
- ChecksumE1DA876C21F27455
Keywords
- Technical term