A0A7J7EWY4 · A0A7J7EWY4_DICBM
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1240 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | calmodulin binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7EWY4
Proteomes
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 435-554 | Disordered | ||||
Sequence: KKRHQPGTGGPGSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPRLEPQKSLGEEGPQRGPDAVGPTDREDEEEDEEEEEQTDLKKPTTDEGTASSEVNAT | ||||||
Compositional bias | 451-486 | Polar residues | ||||
Sequence: KRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGL | ||||||
Compositional bias | 520-534 | Acidic residues | ||||
Sequence: TDREDEEEDEEEEEQ | ||||||
Domain | 557-673 | PI-PLC Y-box | ||||
Sequence: MSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMR | ||||||
Region | 896-949 | Disordered | ||||
Sequence: AQAGPETCQETQSQQLGSQLTPNPTPGPVDASPRRPPGPVTSPTSPSLGSPGQR | ||||||
Compositional bias | 899-920 | Polar residues | ||||
Sequence: GPETCQETQSQQLGSQLTPNPT | ||||||
Compositional bias | 921-939 | Pro residues | ||||
Sequence: PGPVDASPRRPPGPVTSPT | ||||||
Coiled coil | 1079-1170 | |||||
Sequence: LDAHTTQLKRLKEINEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQKQRQERLVAGQQQVLQQLVEE | ||||||
Region | 1213-1240 | Disordered | ||||
Sequence: CASNGHAPGSSGHLSGADLESQEENTKL |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length1,240
- Mass (Da)139,271
- Last updated2021-04-07 v1
- ChecksumEB60BB7F3809EE34
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: E | ||||||
Compositional bias | 451-486 | Polar residues | ||||
Sequence: KRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGL | ||||||
Compositional bias | 520-534 | Acidic residues | ||||
Sequence: TDREDEEEDEEEEEQ | ||||||
Compositional bias | 899-920 | Polar residues | ||||
Sequence: GPETCQETQSQQLGSQLTPNPT | ||||||
Compositional bias | 921-939 | Pro residues | ||||
Sequence: PGPVDASPRRPPGPVTSPT |
Keywords
- Technical term