A0A7J7EWY4 · A0A7J7EWY4_DICBM

Function

function

Catalyzes the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site299
Binding site300Ca2+ (UniProtKB | ChEBI)
Binding site329Ca2+ (UniProtKB | ChEBI)
Binding site331Ca2+ (UniProtKB | ChEBI)
Active site346
Binding site380Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncalcium ion binding
Molecular Functioncalmodulin binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processlipid catabolic process
Biological Processphosphatidylinositol-mediated signaling
Biological Processrelease of sequestered calcium ion into cytosol

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • ORF names
      HPG69_017878

Organism names

Accessions

  • Primary accession
    A0A7J7EWY4

Proteomes

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

TypeIDPosition(s)Description
Region435-554Disordered
Compositional bias451-486Polar residues
Compositional bias520-534Acidic residues
Domain557-673PI-PLC Y-box
Region896-949Disordered
Compositional bias899-920Polar residues
Compositional bias921-939Pro residues
Coiled coil1079-1170
Region1213-1240Disordered

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,240
  • Mass (Da)
    139,271
  • Last updated
    2021-04-07 v1
  • Checksum
    EB60BB7F3809EE34
EASSRNLVTLRVDANGFFLYWTGPNMEVDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVAGPDPVNTTFLNFMAVQDDTAKVWSEELFKLAVNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPAQARQLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLTADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPGTGGPGSSVRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPRLEPQKSLGEEGPQRGPDAVGPTDREDEEEDEEEEEQTDLKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKAMEVWVSLSDVRLSLGLGGCGQLWLSGLSGCRLAPWLSASLHPQVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLIYTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQAGPETCQETQSQQLGSQLTPNPTPGPVDASPRRPPGPVTSPTSPSLGSPGQRDDLVASILSEVTPAPLDELRGHKALVKLRSRQERDLRELQKKHQRKAMALTRRLPDGLAQARAEGRCRPQPGVLGGENEKEEEEVKRHQEFQKRQVQSLLELREAQADTEAERRLEHLRQAQQRLREVVLDAHTTQLKRLKEINEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEINRRHITESVNSIRRLEEAQKQRQERLVAGQQQVLQQLVEEEPKLLAQLAQECQEQRARLPQEIRRSLLGETPEGLGDGRLVACASNGHAPGSSGHLSGADLESQEENTKL

Features

Showing features for non-terminal residue, compositional bias.

TypeIDPosition(s)Description
Non-terminal residue1
Compositional bias451-486Polar residues
Compositional bias520-534Acidic residues
Compositional bias899-920Polar residues
Compositional bias921-939Pro residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010002094
EMBL· GenBank· DDBJ
KAF5920310.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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