A0A7J7EUE5 · A0A7J7EUE5_DICBM

Function

function

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Activated by RHOA binding. Inhibited by Y-27632.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site105ATP (UniProtKB | ChEBI)
Active site198Proton acceptor

GO annotations

AspectTerm
Cellular Componentbleb
Cellular Componentcentriole
Cellular Componentcytoplasmic stress granule
Cellular ComponentGolgi membrane
Cellular Componentlamellipodium
Cellular Componentplasma membrane
Cellular Componentruffle
Molecular FunctionATP binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionmetal ion binding
Molecular FunctionRho-dependent protein serine/threonine kinase activity
Molecular Functionsmall GTPase binding
Biological Processactomyosin structure organization
Biological Processcortical actin cytoskeleton organization
Biological Processembryonic morphogenesis
Biological Processmitotic cytokinesis
Biological Processpeptidyl-threonine phosphorylation
Biological Processregulation of cell junction assembly
Biological ProcessRho protein signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Rho-associated protein kinase
  • EC number

Gene names

    • ORF names
      HPG69_003844

Organism names

Accessions

  • Primary accession
    A0A7J7EUE5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, coiled coil.

Type
IDPosition(s)Description
Domain76-338Protein kinase
Domain341-409AGC-kinase C-terminal
Coiled coil432-898
Domain479-556REM-1
Coiled coil938-983
Domain949-1015RhoBD
Coiled coil1020-1100
Domain1118-1317PH
Domain1228-1283Phorbol-ester/DAG-type

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,361
  • Mass (Da)
    158,972
  • Last updated
    2021-04-07 v1
  • Checksum
    AF7677AC5D0B9299
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPSDNRTSSNVDKSLQENLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLAQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAALEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMFTHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSLEEAKSVAMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELGQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHAVSRLEETNSMLTKDIELLRKENEELIEKMRKAEEEYKLKKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSIPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTSQGVIDSV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010002401
EMBL· GenBank· DDBJ
KAF5919204.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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