A0A7J7EPE3 · A0A7J7EPE3_DICBM

Function

function

Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site122Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site124Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site131Zn2+ 2 (UniProtKB | ChEBI)
Binding site132Zn2+ 1 (UniProtKB | ChEBI); catalytic
Active site199Schiff-base intermediate with substrate
Binding site223Zn2+ 2 (UniProtKB | ChEBI)
Active site252Schiff-base intermediate with substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionporphobilinogen synthase activity
Molecular Functionzinc ion binding
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Delta-aminolevulinic acid dehydratase
  • EC number

Gene names

    • ORF names
      HPG69_013508

Organism names

Accessions

  • Primary accession
    A0A7J7EPE3

Proteomes

Subcellular Location

Interaction

Subunit

Homooctamer; active form. Homohexamer; low activity form.

Family & Domains

Sequence similarities

Belongs to the ALAD family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    325
  • Mass (Da)
    35,349
  • Last updated
    2021-04-07 v1
  • Checksum
    4FEB869572C1395C
MQPQSVLHSXXXXPLLRTWQAASTTLNASNLIYPIFVTDVPDDVQPIASLPGVARYGVNRLEEMLRPLVEEGLRCVLVFGVPSRVPKDERGSAADSEDSPTIEAVRLLRKTFPSLLVACDVCLCPYTSHGHCGLLSENGALQAKESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKDALMAHELGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMVMVKPGMPYLDIVREVKNKHPELPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTALRRAGNQVEGGVDVCHRDR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JACDTQ010002517
EMBL· GenBank· DDBJ
KAF5917672.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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