A0A7J7EHY9 · A0A7J7EHY9_DICBM
- ProteinCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids342 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- ganglioside GM1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GD1a (18:1(4E)/18:0) + CMP + H+This reaction proceeds in the forward direction.
- a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H+This reaction proceeds in the forward direction.
- a ganglioside GA1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b (d18:1(4E)) + CMP + H+This reaction proceeds in the forward direction.
Pathway
Glycolipid biosynthesis.
Protein modification; protein glycosylation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 107 | substrate | |||
Binding site | 149 | substrate | |||
Binding site | 172 | substrate | |||
Binding site | 232 | substrate | |||
Binding site | 268 | substrate | |||
Binding site | 272 | substrate | |||
Binding site | 292 | substrate | |||
Binding site | 301 | substrate | |||
Binding site | 318 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | Golgi cisterna membrane | |
Molecular Function | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity | |
Biological Process | ganglioside biosynthetic process via lactosylceramide | |
Biological Process | protein glycosylation | |
Biological Process | sialylation |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7EHY9
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus, Golgi stack membrane ; Single-pass type II membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Disulfide bond | 144↔283 | ||||
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length342
- Mass (Da)39,234
- Last updated2021-04-07 v1
- ChecksumF660203D5F61A952
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACDTQ010002883 EMBL· GenBank· DDBJ | KAF5915303.1 EMBL· GenBank· DDBJ | Genomic DNA |