A0A7J7ECI2 · A0A7J7ECI2_DICBM
- ProteinCysteine dioxygenase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids205 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen.
Catalytic activity
- L-cysteine + O2 = 3-sulfino-L-alanine + H+This reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe cation per subunit.
Pathway
Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 86 | Fe cation (UniProtKB | ChEBI); catalytic | |||
Binding site | 88 | Fe cation (UniProtKB | ChEBI); catalytic | |||
Binding site | 140 | Fe cation (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | cysteine dioxygenase activity | |
Molecular Function | ferrous iron binding | |
Biological Process | L-cysteine catabolic process | |
Biological Process | taurine biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCysteine dioxygenase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Rhinocerotidae > Diceros
Accessions
- Primary accessionA0A7J7ECI2
Proteomes
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Cross-link | 93↔157 | 3'-(S-cysteinyl)-tyrosine (Cys-Tyr) | |||
Keywords
- PTM
Structure
Sequence
- Sequence statusComplete
- Length205
- Mass (Da)23,539
- Last updated2021-04-07 v1
- MD5 Checksum6FB0F8AD0119A1E11673CAA0BE18C8CD
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JACDTQ010003641 EMBL· GenBank· DDBJ | KAF5913520.1 EMBL· GenBank· DDBJ | Genomic DNA |